| Objective:to study the ill information, clinical expressions, features pathology,diagnosis and treatment, sound prognostic several factors of gastroinstestinal stromaltumor(GIST).Methods: from January2006to October2012，GIST146patients were treated atthe NO1Hospital Affiliated to Da lian medical University, The clinicalpathologic andclinical data were analyzed retrospectively.Results: females80and males66, among the patients youngest is27,oldest is87,The mean age was60.3years, The clinical presentations were different with tumorsites. Physical examination40cases(27.4%), abdominal pain48cases(32.8%),hematic urinate20cases(13.7%), abdominal bump12cases (8.2%), spitting blood5cases(3.4%), intestinal obstruction3cases(2.1%), become thin3cases(2.1%),2or moresymptom15cases(10.3%). Tumors located in the esophagus in3cases(2.1%), stomachin89cases(61.0%), duodenum in13cases(8.9%), small intestine in28cases(2.7%),colon in4cases(2.7%), rectum in5cases(3.4%),appendix in1cases(0.7%),2or moreorgans in3cases(2.1%) respectively．All the tumor of the patients were removedthrough surgeon, and proved to be the GIST through pathology. CD117(+)132(90.4%),CD34(+)122(84.0%),S-100(+)25(17.1%), actin(+)29(19.9%). After thesurgeon85are retumed a visit63of85(74.1%)are well,and220f85(25.9%)are dead,45of63keep review after surgeon,90f63keep imatinib over1year. The22of85aredead after surgeon because relapse and metastasis.Conclusion:The years are main middle-aged and elderly. There are nooutstandingdifferences between man woman, very low incidence of young people; GIST pathol-ogy mainly as CD117(+) andCD34(+); Clinical symptoms for patients of GIST have nospecific before surgery to confirm the diagnosis very little, mostly through the pos-tperative pathological diagnosis. GIST most effective treatment is surgical remove; Themain factors affecting the prognosis of gender,tumor size, mitotic index, preope-rative metastasis; Molecular targeted therapy for GIST provides a new means of adjuvanttherapy. |
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