| ObjectiveTo investigate the relationship between the positive proportion of serologicalindicators and the clinical symptoms of rheumatoid arthritis (RA).MethodsAll patients (48man and171women) had a diagnosis of RA using RAclassification criteria of American rheumatism association (ACR) from June2010toJune2012. The serological and clinical data of patients were collected, includingage, gender, course of disease, past disease history, clinical symptoms and signs,outcomes of X-ray, anti-CCP antibodies, AKA, APF and RF. Chi-square test and ttest were used to analyze the data.ResultsThe average age of the patients was62.38±12.97years old, which165cases(75.4%) aged50-79years formed the majority of patients. The ratio of male tofemale was1:3.57. The average age of onset in female (60.89±13.16years old) wasearlier than that in male (67.35±11.01years old)(t=3.066, P=0.002). The joint painand swelling in patients aged60-69was more than ones aged70-79(χ~2=8.559，P=0.003). Of the patients,205(93.6%) had joint pain and swelling, and100(45.7%)occurred bone destruction. Moreover,72(32.9%) showed joint deformities. Thereexisted the significant difference in joint deformities observed in different pastdisease history of RA patients (P=0.038). The positive proportion of male patientswith joint pain (85.4%) was lower than that in female patients (95.9%)(correctionχ~2=5.25, P=0.022). The significant difference in bone destruction was observed indifferent courses of disease of RA (χ~2=32.073, P<0.001). The bone destruction inpatients whose courses of disease were more than12months (57.8%) was more serious than that whose courses of disease were less than6months (8.0%)(χ~2=21.336,P<0.001) or between6and12months （22.5%）（χ~2=15.821, P<0.001）. Thereexisted the significant difference in joint deformities observed in different courses ofRA (χ~2=29.997, P<0.001). The joint deformities in patients whose courses of diseasewere more than12moths（44.2%）was significantly higher than those whose coursesof disease were less than6moths（4.0%）(χ~2=14.641, P<0.001) or between6to12moths (7.5%)(χ~2=18.387, P<0.001). The RF-positive (204), CRP-positive (177),anti-CCP antibody-positive (147), AKA-positive (87) and APF-positive (55) patientsaccounted for93.2%,80.8%,67.1%,39.72%and25.11%respectively. Furthermore,there was significant difference in anti-CCP antibody positive proportion observed indifferent courses of disease of RA (χ~2=14.978，P=0.001). In addition, the positiveproportion of anti-CCP antibody, CRP observed in the courses of RA (＞12months)was higher than those (6-12months)(χ~2=5.924, P=0.015) or less than those (＜6moths)（χ~2=12.276, P<0.001）. There was significant difference of positiveproportion in the courses of RA (χ~2=30.379, P<0.001). The positive proportion ofCRP (＜6months) was lower than those（6-12month: χ~2=14.245, P<0.001;＞12months: χ~2=28.776, P<0.001）. The patients with bone destruction had higherpositive proportion of anti CCP antibody, CRP, AKA than those without bonedestruction (χ~2=16.059, P<0.001; χ~2=6.118, P=0.013; χ~2=9.769, P=0.002;respectively). The patients with joint deformities had a higher positive proportion ofanti-CCP antibody, AKA, APF than those without joint deformity（60.5%）（χ~2=8.77,P=0.003; χ~2=13.281, P<0.001; χ~2=8.75, P=0.003; respectively）. RA patients withjoint swelling had a higher positive proportion of CRP than those with joint swelling(correction χ~2=16.647, P <0.001).ConclusionRA patients with bone destruction have a higher positive proportion of anti-CCPantibody, CRP and AKA than those without bone destruction. The patients with jointdeformities have a higher positive proportion of anti-CCP antibody, AKA and APFpositivity than those without joint deformities. The patients with joint swelling pain have a higher positive proportion of CRP positivity than those without joint swellingpain. |
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