Evaluate The Relationship Of Coronary Artery Distensibility With The Main Risk Factors Of Coronary Artery Disease Measured By CTA

ObjectiveEvaluate the relationship of coronary artery distensibility with the main risk factors ofcoronary heart disease measured by computed tomographic angiography （CTA）.Materials and methods118subjects were studied,43cases healthy people （men14, mean age,56±4y）,25cases with high blood pressure,（men12, mean age,60±6y）,31cases with hyperlipidemia（male18, mean age,60±6y）,19cases with diabetes（men9, mean age,59±6y）, measuredblood pressure and underwent coronary CTA scan.End systolic（ES） and mid diastolic （MD） cross-section area （CSA） of the left anteriordescending （LAD） artery7mm distal to the left main bifurcation were measured，CDI wasdefined as （CDI）=[（CSA in end systolic-CSA in mid diastolic）/（pulse pressure×CSA indiastolic middle）]*1000, pulse pressure was defined as difference of brachial arterysystolic blood pressure and diastolic blood pressure, compared the difference of CDI.ResultsCDI of patients with hypertension, hyperlipidemia, diabetes were3.66±1.39mmHg^-1×10³ï¼Œ3.72±1.39mmHg^-1×10³ï¼Œ3.30±0.84mmHg^-1×10³respectly，CDI of healthysubjects were5.24±1.40mmHg^-1×10³. Compared with the healthy subjects，CDI ofpatients with hypertension, hyperlipidemia, ordiabetes were reduced obviously（P <0.001）.ConclusionCDI of patients with hypertension, hyperlipidemia, diabetes were significantlydifferent with healthy subjects，but there were no significantly difference in the threegroups。Thus it can conclude that hypertension, hyperlipidemia, diabetes can reduce thedistensibility of coronary artery. CDI is obviously effected by known major risk factors of coronary heart disease, CDI can assess the degree of vascular dysfunction reliablely.