Outcome Of LRYGB In Treatment Of Type2Diabetes Mellitus In Non Morbidly Obese

PurposeTo observation the outcome of laparoscopic Roux-en-Y gastric bypass(LRYGB) in treatment of type2diabetes mellitus in non-morbid obesepatients.MethodsTen type2diabetic patients undergoing LRYGB with gender (30%female),age (mean49.6±8.6years),body mass index (BMI,28.9±3.6kg/m2),duration of diabetes (9.5±3.4years) were studied. Follow-up in12months postoperatively. T2DM resolution defined as stopping ofantidiabetic treatment，fasting plasma glucose <5.6mmol/L, and HbA1C<6.0%. Remission defined as still need small dose of antidiabetic drug,fasting plasma glucose＜7.0mmol/L and HbA1c＜6.5%. Observation afteroperation on blood glucose, blood fat and blood pressure, weight,medication dosage changes and postoperative complications of patients.RESULTSAt the12month postoperatively，resolution of diabetes was observed in5patients （50%） while the other5patients（50%） was remission. Theduration of diabetes in resolution group is obviously short than remissiongroup（4.5±2.9years vs11.0±2.3years， P=0.036）.But there was nosignificant difference in age、 B MI、 WHR、 FPG、FCP and HbA1cbetween the two groups（P﹥0.05）;The resolution rate of the group whichduration of diabetes＜10years was80%,while the other group whichduration of diabetes≥10years was only20%。All the patients withcomplications of dyslipidemia, hypertension patients stopped all thelipid-lowering or antihypertensive drugs. None of those patients deadpostoperatively.1cases suspected intestinal obstruction (10%) after3months of operation.CONCLUSIONSLRYGB is a safe and effective treatment for type2diabetes in nonmorbidly obese patients, and can effectively control dyslipidemia andhypertension.The research also indicated that the duration of diabetes maybe a negative predictor of efficacy to gastric bypass operation.