| ObjectiveTo analysize the number of pregnancy of women with type O bloodeffects on severity of ABO hemolytic disease of newborn(ABO hemolyticdisease of newborn,ABO-HND); And to explore the distribution of bloodgroup ABO-HND and the relationship between the blood type of children(blood type A or type B blood) with severity.Methods193neonate diagnosed of ABO-HND,admitted in the neonetal centerof children’s hospital of chongqing medical university from September15,2012to February28,2013,and conforming to the criteria0f beselected,were retrospectively analyzed:Firstly,they were divided into twogroups according to the number of mothers’ pregnancies once or not once,pregnancy group for the first time the82cases,111cases of non-firstpregnancy group, to compare the time of jaundice appeared for the firsttime after birth, the serum total bilirubin at the time of admission, albumin,the proportion of reaching shake-standard,hemoglobin, the proportion ofanemia phototherapy time, the number of days of hospitalization, and to compare the results of improved Coombs test, antibody release test,andfree antibody test the two groups.Secondly,in accordance with the ABOblood group of the children,they were divided into type A blood group andtype B blood group, blood type A group of114cases, B-type blood groupof79cases, same to compare the time of jaundice appeared for the firsttime after birth, the serum total bilirubin at the time of admission, albumin,the proportion of reaching shake-standard,hemoglobin, the proportion ofanemia, phototherapy time, the number of days of hospitalization, and tocompare the results of improved Coombs test,antibody release test,and freeantibody test the two groups.Result⑴The difference between first pregnant group and non-first time withthe time of jaundice appeared for the first time after birth, the serum totalbilirubin at the time of admission, hemoglobin, albumin, phototherapy timeand hospitalization days of first pregnant group and non-first time was nosignificant, were not statistically different (P>0.05).they were respectively(38.59±28.08) vs (40.52±29.07) h,(288.86±93.20) vs (309.84±104.34)μmol/L,(147.73±21.91) vs (149.14±22.37) g/L,(35.67±4.07) vs(35.79±3.67) g/L,(67.35±29.92) vs (68.83±26.83) h,(7.59±1.35) vs(7.72±1.48) days. The difference between the two groups with theproportion of anemia, the proportion of reaching shake-standard and theresults of improved Coombs test,antibody release test and free antibody test were not statistically different (P>0.05).⑵The difference between type Ablood group and type B blood group,with the time of jaundice appeared for the first time after birth, the serumtotal bilirubin at the time of admission, hemoglobin, albumin, phototherapytime and hospitalization days of first pregnant group and non-first time wasno significant, were not statistically different (P>0.05).they wererespectively (41.56±26.70) vs (37.03±31.12) h,(297.23±102.34) vs(306.25)±(97.05) μmol/L,(150.18±21.40) vs (145.82±22.94) g/L,(35.96±3.86) vs (35.427±3.81) g/L,(67.04±28.54) vs (69.87±27.59),(7.61±1.41) vs (7.73±1.46) days. The difference between the two groupswith the proportion of anemia, the proportion of reaching shake-standardand the results of improved Coombs test,antibody release test and freeantibody test were not statistically different (P>0.05).ConclusionThe time of jaundice appeared for the first time after birth, the serumtotal bilirubin at the time of admission, albumin, the proportion of reachingshake-standard,hemoglobin, the proportion of anemia, phototherapy time,the number of days of hospitalization of ABO hemolytic disease of thenewborn have nothing to do with the number of mother’s pregnancy and theblood type of children(blood type A or type B blood); The results of theimproved Coombs test, antibody release test and free antibody test werealse no significant correlation with them. ABO hemolytic disease of the newborn, regardless of whether the mother was the first pregnancy, andregardless of the children with blood type A or type B blood, should arouseenough attention of clinicians to achieve early diagnosis, early treatment, inorder to reduce bilirubin encephalopathy. neurological sequelae and deathoccurred.In the paper,the children with blood type A is more than the onewith blood type B, this may be result from the distribution of thepopulation with blood group gene. |
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