The Therapeutic Effect Of Bronchial Alveolar Lavage And The Pulmonary Function For Bronchiolitis Obliterans

PART I THE THERAPEUTIC EFFECT OF BRONCHIALALVEOLAR LAVAGE FOR BRONCHIOLITISOBLITERANSObjective：To analysis the therapeutic effect of bronchial alveolarlavage（BAL）in infants’ bronchiolitis obliterans.Methods：Review14cases of BO which were diagnosed in Children’shospital of ChongQing Medical University in Jan2011to Oct2012，ofwhich including the treatment group(8cases)and the contrast group (6cases),The treatment group’s treatment is common anti-infection、anti-inflammatory and asthma relieving therapy,they also have BAL withbudeaonide and mucosolvan.the contrast group is commonanti-infection、anti-inflammatory and asthma reliving therapy.Compare theclinical manifestation and clinical prognosis between the two groups in5to7days.Results:With the fiberbronchoscopy,3cases were stenosis in the bronchial opening,2cases were moderate to severe tracheobronchomalacia(TBM),2cases were with both stenosis and evere TBM.Treatment group:3cases significant effect,4cases effective,1cases ineffectiveness;Contrastgroup:1cases effective,5cases ineffectiveness.The effective rate oftreatment group(87.5%) is higher than the contrast group(16.7%),thedifference is significant(P＜0.05).Conclusion:The BAL could improve the short term therapeuticefficacy of BO observably.Few infants with BO were combined with TBM. PART II THE PULMONARY FUNCTION OFBRONCHIOLITIS OBLITERANSObjective：To analysis the pulmonary function of the post-infectiousbronchiolitis obliterans in infants.Methods：Analysis14cases of post-infectious BO from Jan2010toNov2012which were diagnosed in Children’s hospital of chongQingMedical University,about their pulmonary function(tPTEF/tE、VPEF/VE、PF/V25、ME/MI and the improve rate）TBFV loop，compare the pulmonary function （tPTEF/tE、VPEF/VE、PF/V25and ME/MI）of the treatment groupand the contrast group in5to7days.Results：Airway obstruction:tPTEF/tE:mild1case,moderate5cases,severe8cases; VPEF/VE:mild2cases,moderate6cases,severe6cases;PF/V25:mild1case;moderate3cases,severe10cases;ME/MI:mild3cases,moderate9cases,severe2cases.The BDT:VPEF/VE1case(7.1%) positive,PF/V254cases positive.TBFV loops are depressed to the volume line. Thedifference of the pulmonary function（tPTEF/tE、VPEF/VE、PF/V25andME/MI）before the treatment between two groups is small(P＞0.05), thepulmonary function（tPTEF/tE、VPEF/VE、PF/V25and ME/MI）differencebefore and after the BAL of the treatment group is significant(P＜0.05),thedifference of the contrast group pulmonary function（tPTEF/tE、VPEF/VE、PF/V25and ME/MI）before and after the treatment is small (P＞0.05).Conclusion:The tPTEF/tE、VPEF/VE、PF/V25indicate the airwaymoderate to severe obstruction;BAL could relieve the BO infants’ airwayobstruction and improve the lung function in short term.