Relationship Between The Expression Of HRAS And HMGA1and Tumor Invasion In Pituitary Adenomas

Objective：To investigate the expression levels of V-Ha-Ras HarveyRat Sarcoma Viral Oncogene Homolog（HRAS） and High Mobility GroupAT-hook1（HMGA1）in the pituitary adenomas and their relationshipswith tumor invasion in human pituitary adenomas.iMethod：sixty specimens of pituitary adenomas were classified intoinvasive and non-invasive groups according to the comprehensiveevaluation of invasive pituitary adenoma. The protein and mRNAexpression levels of HRAS and HMGA1were detected usingimmunohistochemistry assay、western blot assay and reverse transcriptionpolymerase chain reaction(RT-PCR)assay,respectively．Results：There were twenty-eight cases of invasive pituitary adenomasand32cases of non-invasive ones in total60specimens．The protein andmRNA expression levels of HRAS were significantly higher in invasivegroup than that in non-invasive group （P＜0．05）．The protein and mRNAexpression levels of HMGA1were significantly higher in invasive groupthan that in non-invasive group（P＜0．05）． Conclusion：The present findings suggest that up-regulation of HRASand HMGA1can contribute to tumor invasion in human pituitaryadenomas.