The Occurrence, Prediction And Impact Of Sleep-related Hypoxemia Among Chronic Obstructive Pulmonary Disease Patients In Stable Stage

Objective: Sleep-related hypoxemia (SRH) is found to occur in patients with chronicobstructive pulmonary disease (COPD), but its occurrence and impact are still lack of depthunderstanding. Wrist pulse oximeter is applied in this study, for long-term oxygensaturation monitoring among stable COPD patients, to diagnosis sleep-related hypoxemiaand calculate its incidence; to analyze the possible predictors that provide as references forthe investigation of high-risk patients; to have a statistics of clinical information forlearning the impact of SRH.Methods: Stable COPD patients87cases. After collecting a detailed history of all selectedobjects, the blood was drawn out by day care workers for arterial blood gas analysis, andthey had to fill out the Pittsburgh Sleep Quality Index Scale (PSQI) and the Cough Scoreunder the guidance of the technicians. Wrist pulse oximeter was applied for long-termoxygen saturation monitoring in the same evening. Total sleep time over five hours reachedthe inclusion criteria. Divided into two groups according to the results of the long-termoxygen saturation monitoring, all data would be compared between groups.Results: The incidence of SRH was26.4%. Compared to the NSRH group, SRH patients had a greater tendency to develop hypercapnia. PaO2(P <0.05), PaCO2(P <0.05) and PSQI(P <0.01) could be seen as independent predictors of SRH. The ROC curve showed thatPSQI≥10, PaO2≤63.5mmHg and PaCO2≥49.0mmHg were the best diagnostic cut-offpoints. There were statistically significant differences that SRH group had higher incidenceof arrhythmias and higher number of hospitalizations (P <0.05).Conclusion: According to the results of this study, the PSQI, PaO2and PaCO2could beused as predictors of SRH. PSQI≥10or (PaO2≤63.5mmHg and PaCO2≥49.0mmHg) wasa prediction formula as reference. COPD with SRH could bring a worse prognosis forpatients, and long-term oxygen saturation monitoring for screening patients in need oftreatment is a necessity.