| Objective： To investigate the prevalence of PAD in patients with type2diabetes andanalyzed the risk factors associated with PAD.Methods：A total of917patients with type2diabetes who underwent ankle-brachialindex(ABI) measurement in Tongji Hospital were enrolled. PAD was defined as an ABI≤0.9. Clinical characteristics of40patients with PAD were compared with those of120age-and sex-matched control patients without PAD.Results：Of the917type2diabetic patients,40(4.4%) were diagnosed as PAD. PAD wasassociated with higher prevalence of retinopathy, nephropathy, neuropathy and smoking.Patients with PAD had higher systolic blood pressure,fasting serum insulin level,HOMA-IR and LDL-C. Multivariate analysis showed that long duration of diabetes,smoking, high LDL-C, high systolic blood pressure and the presence of microvascularcomplications are risk factors independently associated with PAD.Conclusion：The prevalence of PAD in diabetic patients was4.4%. Long duration ofdiabetes, smoking, high LDL-C, high systolic blood pressure and the presence of microvascular complications are factors independently associated with PAD. Objective: To investigate the prevalence of sub-clinical PAD in patients with diabetes andanalyzed the factors associated with sub-clinical PAD.Methods: Color Doppler ultrasound was applied to detect patients’bilateral femoral artery,popliteal artery, anterior tibial artery and posterior tibial artery and carotid artery status. Atotal of601patients with type2diabetes who underwent ankle-brachial index(ABI)measurement and color doppler ultrasound examination in Tongji Hospital were enrolled.Sub-clinical PAD was defined as an ABI>0.9but Doppler ultrasound showed abnormal.Using the Doppler ultrasound results, the patients were stratified into four groups, whichincluded215patients in the normal group,172patients in the lower extremity arterydisease group,52patients in the carotid artery disease group and162patients in themulti-position group.Result: Of the601type2diabetic patients,386(62.2%) were diagnosed as sub-clinicalPAD. Compared to the normal group, patients with sub-clinical peripheral arterial diseasehad lower triglyceride, fasting and postprandial insulin level. Sub-clinical PAD wasassociated with higher prevalence of diabetic nephropathy and coronary disease.Conclusion: The prevalence of sub-clinical PAD was62.2%. Objective: To investigate the prevalence and risk factors of diabetic foot in in-patients and study the clinical characteristics of diabetic foot ulceration such as predilection sites,contributors and infectious bacteria spectrum.Methods:62patients with diabetic foot ulcers were enrolled to the third part. The clinicalcharacteristics of the62patients were retrospectively studied. Logistic multiple regressionwas used to screen the risk factors of foot ulcers. Based on the cause of the foot ulcers, wedivided the62people into3groups which were nervous group, ischemic group and mixedgroup.Results: Compared to the control group, patients with diabetic foot had higher prevalenceof hypertention, peripheral arterial disease, peripheral neuropathy, diabetic nephropathyand diabetic retinopathy. Diabetic foot was associated with the increases of age andduration. Higher serum uric acid, lower triglyceride and total cholesterol level were alsoapplied to diabetic foot. Logistic multiple regression analysis exhibited that the presenceof peripheral arterial disease and diabetic nephropathy were closely related to theoccurrence of diabetic foot. Most of the incentives of foot ulcers (62.8%) were frompatients paying no attention to the details in daily life, which can be completely avoided.With the increase of Wagner grade and infection grade, the length of hospitalizationgradually increased, the healing situations of foot ulcers became worse and amputationrate increased. In the infectious bacteria spectrum, gram positive coccus was the mostcommon. And they were resistant to penicillin, erythrocin and gentamicin, but weresensitive to vancomycin, linezolid and teicoplanin.Conclusion: The prevalence of diabetic foot in in-patients was4.3%. Wagner grade andinfection grade can predict the healing situation. After the effective medical treatment,72.6%diabetic patients would be improved. |
PDF Full Text Request