Assessment Of Differences In Deformation Ventricular Septum Before And After Percutaneous Closure Of Atrial Septal Defect Using Two-dimensional Ultrasound Speckletracking Imaging

Part1Assessment of differences in deformation between the left andright sides of the ventricular septum in patients with atrial septal defectusing two-dimensional ultrasound speckle tracking imagingObjective：The aim of our study was to assess the differences in deformationbetween the left and right sides of the ventricular septum in patients with atrial septaldefect(ASD) and normal persons using two-dimensional ultrasound speckle trackingimaging(STI).Methods：20patients with ASD and20age-matched normal controls werestudied. Longitudinal peak systolic strain on both sides of the ventricular septum wasobtained by STI from the apical4-chamber view. Radial and circumferential peaksystolic strains on both sides of the ventricular septum were measured by STI fromthe short-axis view of left ventricle (papillary muscle level).Results：①In the control group，the radial and circumferential strain wassignificantly higher on the left than on the right side of ventricular septum, whereaslongitudinal strain on both sides did not significantly differ.②Compared withcontrols, longitudinal and circumferential strain on both sides of ventricular septumwas significantly increased in patients with ASD, whereas radial strain was similar onboth sides.Conclusions: STI can identify the differences in the deformation of both sides ofthe ventricular septum in normal controls. RV volume overload impact on function ofventricular septum by longitudinal and circumferential strain on the left and rightsides of ventricular septum, not by radial strain on both sides. Part2Assessment of differences in deformation between the left andright sides of the ventricular septum before and after percutaneous closureof atrial septal defect using two-dimensional ultrasound speckle trackingimaging.Objective：The aim of our study was to assess the differences in deformationbetween the left and right sides of the ventricular septum before and afterpercutaneous closure of atrial septal defect using STI，and to explore the correlationbetween the above deformation and right ventricular function.Methods：20percutaneous closure of ASD and20normal controls were studied.On1week before and3days after closure, longitudinal peak systolic strain on bothsides of the ventricular septum was obtained by STI from the apical4-chamber view.Radial and circumferential peak systolic strain on both sides of the ventricular septumwas measured by STI from the short-axis view of left ventricle (papillary musclelevel). Tricuspid annulus peak systolic velocity (TAPSE) was measured by twodimension M-mode ultrasound at the right ventricular free wall. Right ventricularfractional area change (RVFAC) was calculated by two dimension ultrasound from theapical4-chamber view.Result：①Longitudinal and circumferential strain on the left and right sides ofventricular septum were significantly lower in the postoperative ASD than those in thepreoperative ASD（P<0.05for all）.whereas radial strain was similar on both sideswith preoperative and postoperative ASD.②TAPSE had negative correlation withlongitudinal strain on both sides of ventricular (left r=-0.833,p=0.0083；right r=-0.47，p=0.038). Whereas the correlations between the TAPSE and radial and circumferentialstrains on both sides of ventricular septum were not found in our study. RVFAC had no correlation with longitudinal, radial and circumferential strain on both sides ofventricular septumConclusion：Strain on both sides of the ventricular septum were decreased inpostoperative ASD compared with preoperative ASD, STI can defect the changes indeformation on the left and right sides of the ventricular septum before and afterclosure of ASD.