Discuss A Number Of Issues On Multiple Myeloma Free Light Chain Detection

[Objective]: Discussing the clinical significance of measuring Free Light Chain.[Methods]:Collection55multiple myeloma patients whose the ratio of kappa serum freelight chain and lambda serum free light chain was abnormal;and collection93patientswith multiple myeloma, relatively consistent rate of total light chain urinary free lightchain in urine.Then to compare the detection rates of them.[Results]:The23patients were not detected or misdiagnosed when we used the SerumTotal Light Chain measurement.The misdiagnosis rate reached41.82%.What’s more,thestudy doesn’t get the relationship with the quantity of Serum Free Light Chain.When weused the Urine Total Light Chain measurement,93multiple myeloma (multiple myeloma,MM) patients88cases of urinary free light chain and urine total light chain match.The misdiagnosis rate reached5.4%.P <0.001, there was a significant difference.[Conclusions]:The detected rate of the Serum Total Light Chain measurement was quitelow.And it was no rules to follow.In a word,it was no clinical reference value.Clinicalmultiple myeloma patients detect urinary light chain myeloma full set of single urine totallight chain. [Objective]: Discussion Serum involvement of the concentration of the light chain ofimpaired renal function patients with multiple myeloma.[Methods]:Collection of80MM patients with newly diagnosed, were used to detect theinvolvement sFLC concentration and serum creatinine concentration, and the two-linecorrelation.[Results]:Patient involvement lower sFLC concentration was no correlation betweenserum creatinine.When the sFLC reached a critical value (sFLC-κ>113mg/L, sFLC->278mg/L), especially sFLC-κ>113mg/L when there was a significant correlation withserum creatinine,without sFLC-□>278mg/L[Conclusions]:The sFLC not the main reason to cause renal dysfunction in patients with multiple myeloma in the early. With the development of the disease, especially sFLC-κ>113mg/L,sFLC was the main reason caused by multiple myeloma patients with renalimpairment. Mechanism for pathogenic to be studied.