Effect Of Alcohol And Metabolic Factors On Hepatic Fibrosis In The CHB Patients

Aim: To understand the difference in the CHB patients and CHB patients combinedwith fatty degeneration between the characteristics of hepatic pathological changes andclinical changes, and to search the risk factors associated with the degree of hepaticfibrosis changes.Methods: Analysis of liver biopsy in275patients with newly diagnosed HBsAg positivepatients, On the basis of pathological results, the cases are divided into simple hepatitis Bgroup and hepatitis B combined with fatty degeneration group, use t test to compare withthe diversity between the age, waistline, uric acid, blood fat in two groups,and utilizemultiple linear regression to analyse each risk factor which has an effect on the hepaticfibrosis.Statistical analysis uses SPSS statistical software Statistics17, P <0.05hasstatistical significance.Result:104cases of275patients with steatosis in CHB patients.CHB patients with fattyliver compared with simple CHB patients in the level of waistline, uric acid， TG，LDL,TC，exists statistical significance,combined with fatty degeneration group relatives tothe simple CHB group with greater body mass index (BMI).And fatty degenerationgroup and simple CHB group exist differences on fibrosis level(χ2=5.364, P=0.021).Through multiple regression analysis finds that age, level of inflammation grading,drinking and HBeAg negative status are independent risk factors for exacerbation offibrosis progression in patients with CHB（P all<0.05）. Effect of fat deposition in hepaticfibrosis is negatively correlated, namely the degree of hepatic fibrosis is more heavy, thefat deposition is more light（t=-2.689P=0.008）.Conclusion: The liver biopsy and clinical data show that dyslipidemia, obesity and theother metabolic syndrome is a primary cause of hepatic steatosis, which has nothing to dowith the alcohol factors. Age, levels of inflammation, e antigen negative state, drinking are independent risk factors in CHB patients related to the progress of liver fibrosis,but withthe increase of the degree of fibrosis,hepatic steatosis degree is reduced instead.