Growth Differentiation Factor-15Plasma Level And Genotype:Associations With Coronarv Atherosclerosis Heart Disease

BackgroundGDF-15is a member of the TGF-β cytokine superfamily. It is induced by various forms of stress, such as ischemia-reperfusion injury, pressure overload and tumors. Laboratory animals studies suggest that GDF-15has anti-apoptotic and anti-remodeling effects. Meanwhile, clinic trials suggest that GDF-15is linked to increased risk of CVD and future adverse cardiac events. SNP studies in GDF-15suggest the genotypes are associated with protein function and transcription activity. GDF-15plasma level and genotype may provide diagnostic and prognostic information in patients with CAD.MethodsBlood samples were obtained after CAG from158patients without AMI. GDF-15genotypes were determined by direct sequencing method. Clinical and biochemical information was recorded and all patients were followed up.ResultrslO59519:allele G carriers have a lower risk of UAP [OR=0.494,(95%CI,0.262-0.934); P=0.029]. The genotypes are associated with GDF-15plasma level. Genotype CC group significantly benefits from PCI therapy. rs1059369:allele T carriers have a lower risk of UAP [OR=0.334,(95%CI,0.141-0.791); P=0.010]. allele A carriers significantly benefit from PCI therapy. No three SNPs are associated with the CAD prognosis.ConclusionsGDF-15genotypes are associated with GDF-15plasma level, and provide additional information for risk stratification and therapy decision-making in patients with CAD.