Related Factors For Recurrence And Metastasis Of Breast Cancer After Modified Radical Mastectomy

Objective: To explore the related factors for recurrence and metastasis of breast cancer after radicalmastectomy and its significance.Methods: The clinical and pathological data collected from January2004to December2007in our hospitalunderwent a modified radical mastectomy for the initial treatment, complete follow-up records of257patients with breast cancer. A retrospective analysis of the patient’s age, menopausal status, pathologicaltype, primary tumor size, number of axillary lymph node metastasis, tumor stage, vascular invasion, ER,PR, nm23, P53, and HER-2protein expression, chemotherapy,radiation therapy and endocrine therapy withmetastasis and recurrence.Results:1. Deadline to follow-up date,79cases happened relapse and metastasis in257cases of breastcancer patients,39patients died because of relapse and metastasis. Chest wall is the most common site oflocal recurrence, and bone, liver and lung is the most common sites of distant metastasis, We should focuson review of these parts.2. There were significant differences in the recurrence and metastasis of breastcancer in different pathological types, tumor sizes, numbers of axillary lymph node metastasis, tumor stage,vascular invasions, estrogen receptor, progesterone receptor, nm23and p53protein expressions,chemotherapies, radiotherapies and endocrine therapies(P＜0.05).There were no significant differences indifferent patient’s ages,menopausal situations and HER-2protein expression (P＞0.05). Logisticregression analysis showed that recurrence and metastasis of breast cancer patients with the primary tumorsize, axillary lymph node metastases, vascular invasion, nm23and protein p53protein expression,chemotherapy and endocrine therapy closerelated (P <0.05).Conclusion:1. Recurrence and metastasis of breast cancer is influenced by many factors, these factorsIncluding histological types, tumor size, axillary lymph node metastasis, tumor stage, vascular invasion, ERexpression, PR expression of nm23and P53expression, chemotherapy, radiation therapy and endocrinetherapy or not affect breast cancer recurrence and metastasis.2. Primary tumor size, axillary lymph nodemetastasis, vascular invasion-positive invasive and p53protein positive expression are risk factors forrecurrence and metastasis of breast cancer patients. Nm23protein expression, paclitaxel class jointanthracycline-based chemotherapy and endocrine therapy are protective factors for recurrence andmetastasis of breast cancer patients.3. The age of breast cancer patients, menopausal status and HER-2protein expression were no significant correlation with metastasis and recurrence.4. Individualizedtreatment should be given based on the factors influencing recurrence and metastasis of breast cancer toreduce the risk of recurrence and metastasis and increase survival.5. Breast cancer patients should payattention to the review, to strengthen prevention. Early detection of local recurrence and distant metastasisto give timely remedial treatment is the key to improve the overall survival time.