Analysis On The Levels Of Total Homocysteine And Its Metabolic Factors In Patients With Preeclampsia Between The Uyghur Nationality And The Han Nationality

Object:Testing the levels of plasma total homocysteine （tHcy） and its metabolic factors offolic acid and vitamin B₁₂in patients with preeclampsia and the women in the third trimesterof normal pregnancy,and analyze the relationship between their levels and severity ofpreeclampsia and the differences in the Han nationality and the Uyghur nationality for findingthe experimental basis to diagnose and control the disease development.Methods:Collected207pregnat women form November2011to November2012in People’sHospital of Xinjiang Autonomous Region.The Uyghur nationality: a total of31cases of thethird trimester of normal pregnancy,33cases of mild preeclampsia,and36cases of severepreeclampsia were selected;the Han nationality:a total of38cases of the third trimester ofnormal pregnancy,39cases of mild preeclampsia,and30cases of severe preeclampsia wereselected and there was no significant difference in age and gestational weeks of every group.Then detect plasma tHcy levels measured by ELISA and serum levels of folic acid andvitamin B₁₂measured by ECL.Results:Results:（1）The Uyghur nationality:there was statistically significant difference（P﹤0.01） in the levels of plasma tHcy in the control group, mild preeclampsia group and severepreeclampsia group, and two of them had significant difference （P﹤0.01）;there was nostatistically significant difference in the levels of folic acid in the three group（sP>0.05）;therewas statistically significant difference in the levels of vitamin B₁₂in the three groups（P﹤0.01）,and the mild preeclampsia group is lower than others （P﹤0.01）.（2）The Hannationality:there was statistically significant difference （P﹤0.01） in the levels of tHcy in thecontrol group, mild preeclampsia group and severe preeclampsia group, and two of them hadsignificant difference （P<0.05）;there was statistically significant difference in the levels offolic acid in the three groups（P<0.01）, and the control group is higher than others（P﹤0.05）;there was no statistically significant difference in the levels of vitamin B₁₂in thethree groups（P>0.05）;（3）Comparised the Han nationality with the Uyghur nationality:in thecontrol group:there was no statistically significant difference in the levels of tHcy and vitaminB₁₂（P>0.05）;the levels of folic acid of the Han nationality is higher than the Uyghurnationality（P<0.01）;in mild preeclampsia group:there was no statistically significantdifference in the levels of tHcy and vitamin B₁₂（P>0.05）,the levels of folic acid of the Hannationality is higher than the Uyghur nationality（P<0.01）;in severe preeclampsia group:therewas no statistically significant difference in the levels of plasma tHcy（P>0.05）,the levels offolic acid of the Han nationality is higher than the Uyghur nationality（P﹤0.01）,the levels ofvitamin B₁₂of the Uyghur nationality is higher than the Han nationality（P<0.05）;（4）It wasnot found the correlation of the levels of tHcy,folic acid and vitamin B₁₂in every group of theUyghur nationality and the Han nationality. Conclusion:（1）The levels of tHcy is related to the severity of Preeclampsia in the Hannationality and the Uyghur nationality in Xinjiang,the condition of patients was worse withthe increase of tHcy in plasma. It has certain directive significance to judge the clinicalchanges;（2）there are some differences between the two nationalities in the levels of FA,Vit B₁₂because of the difference in religious beliefs,customs and habits.They are part in themetabolism of tHcy, but tHcy and FA, Vit B₁₂had no obvious correlation.