Effect Of Extended-interval Dosing Regimen Of Gonadotropin Releasing Hormone Agonist In The Treatment Of Adenomyosis

Objective：To study the effect of extended-interval dosing regimen of gonadotropinreleasing hormone agonist(GnRH-a in the treatment of adenomyosis). Methods:48patients suffering from adenomyosis were randomly divided into two groups，extended-interval dosing(study group)and convention dosing(control group)．Patients weretreated with intramuscular injection of GnRH-a either every6weeks of totally four dosesregimen(study group)or every4weeks of six doses regimen(control group). The changesin the degree of dysmenorrhea and uterine volume were investigated. The level of sexualhormone was also detected both before and after therapy. Results: After one year oftherapy，the reliving rate of dysmenorrheal Was99％both in the new and conventionregimen. The uterine volume was reduced，The level of LH，FSH and E2significantlydecreased (P<0.05). The hormone profile of study group Was similar to that of controlgroup(P>0.05). Conclusion: The use of extended-interval dosing regimen of triptorelindepot in adenomyosis results in a consistent hypoestrogenised state，which is similar tothat achieved by conventional regimen. The new regimen significantly reduces the cost oftreatment.