Related Factors Between Type2Diabetes Patients With Hearing Loss And Microvascular Disease

Objective：To research the interrelation between Type2diabetes patients withHearing Loss and Microvascular relevant factors, such as advanced glycation end products(AGEs) and Vascular Endothelial Growth Factor (VEGF).Methods：The levels of AGEsand VEGF were determined by enzyme linked immunosorbent assay (ELISA) in49patie-pnts with T2DM with hearing loss (group A),55patients with T2DM without hearing loss(group B),and47healthy subjects (group C). Results：Body mass index (BMI),totalcholesterol (TC),and uric acid(UA)were not significantly different among three groups (P>0.05),while fasting glucose(FPG),HbA1c,low-density lipoprotein cholesterol(LDL-C),riglycerides (TG)，plasma fibrin(FIB),AGEs and VEGF showed significant differences(P <0.05).Compared with C group,FPG,HbA1c,LDL-C,TG,FIB,AGEs and VEGF Signify-cantly increased in both A and B groups (P<0.05).AGEs and VEGF increased in A groupcompared with B group (P<0.05).In T2DM with hearing loss,AGEs were positively corre-lated with FPG,LDL-C, HbA1c and duration of diabetes (P<0.05).VEGF was positively correlated with FPG, HbA1c,FIB and duration of diabetes (P<0.05).Conclusion：AGEs andVEGF are related with the occurrence and development of T2DM accompanied withhearing loss.AGEs and VEGF may be used as indicators for the early diagnosis and prong-osis of the condition．...