The Value Of The Procalcitonin In The Short-rang Antibiotic Therapy Of Children With Pulmonary Infection

Objective: To combine the traditional inflammation index to systematically assessthe clinical guidance short-range antibacterial treatment value of the procalcitonin(procalcitonin, PCT), and to firstly investigate the clinical value of serum PCT as aquantitative indicator guided the short-range anti-bacterial treatment in the pediatricbacterial pulmonary infections. Methods:90cases of the new department treated Childrenwith the bacterial pulmonary infection needed anti-infection treatment were collected fromOctober in2011to October in2012to conduct a prospective study. They were diagnosedwith Symptoms and signs, PCT more than0.5ng/ml, other laboratory tests and so on. Theywere randomly and equally divided into the experience treatment group and theshort-range anti-bacterial treatment group guided by the PCT(PCT guided group).Tocombine with Symptoms and signs, white blood cell counts, C-reactive protein(CRP)andso on, the experience treatment group were guided empirical antibiotic therapy. Theantibiotic use or non-use was adjusted in the short-range anti-bacterial treatment group bythe results of PCT. Results: In the bacterial lung infection pediatrics, the serum PCT, CRP,WBC levels were all detected to elevate. Compared with the other groups, The PCT levelwas statistically significant (P<0.05), and significantly higher. Compared withexperienced treatment group, the PCT-guided short-course treatment group madeantibiotic exposure reduced, and did not have serious adverse reactive cases. Conclusion:Monitoring dynamically PCT to guide antibiotics use is better than the traditional whiteblood cell counts and CRP, and can reduce the exposure of antibiotics. The PCT can beused as a quantitative index of the short-range anti-bacterial treatment.