Analysis Of Influencing Factors On Serum PSA Levels In Health Examination Cases

Objective The serum Prostate-specific antigen (PSA) testing has been widely used in early diagnosis and curative effect monitoring of Prostate cancer and follow-up observation. However, controversy exists regarding the use of prostate-specific antigen (PSA) testing because of the lack of randomized trials demonstrating a reduction in prostate cancer mortality. Although the prostate-specific antigen (PSA) testing is very sensitive in early diagnosis of Prostate cancer, its specificity limit its use as a screening tool because serum PSA is not tissue specific as well as cancer specific. In addition, the serum PSA concentration is directly correlated with age and prostate volume and is known to be different across ethnic groups. This study was designed to discuss the impact on serum PSA level from anthropometric measurements, the metabolic syndrome (MS) and its diagnostic indicators, liver and kidney function and the lifestyle.Method Collecting1034cases of34-87years old healthy check-up male anthropometry measurements (height, weight, body mass index), lifestyle subjective evaluation indicators (degree of fatigue, sleep status, sleep time, sitting position working hours, weekly workouts, whether smoking or drinking) and clinical detection indicators (blood pressure, height, weight, prostate volume, fasting blood glucose, serum lipids, liver and kidney function indicators), Subjects were divided into the definition of the metabolic syndrome (MS) group and non-metabolic syndrome group, Define group of overweight and obesity according to Working Group on Obesity in China (WGOC) standard, define group of PSA with clinical PSA diagnosis standard3.2ng/mL. Analyze correlation between the Serum PSA and clinical detection indicators, anthropometric measurements, liver and kidney function and lifestyle by univariate and multivariate analysis.Result1034cases of male research object, age34-87years old, Median age58years old. The Serum prostate-specific antigen (PSA) was0.09-55.70ng/mL,73cases in elevated PSA group, accounting for7.06%. The serum PSA levels of MS patients, overweight or obesity, elevated triglycerides group is significantly lower than the corresponding indicators of normal group (P<0.05); The serum PSA level is significantly influenced by the MS, the prostate volume and age, But the influence is not significant in PV normal and low age group object; The serum PSA level with MS and the growth of the number of MS diagnostic indicators of abnormal indicators show a gradual decreasing trend in PV increases group of objects (P-trend<0.05). There were significant differences in anthropometry measurements (height, weight, body mass index) and creatinine clearance rate (CCR) between the resistance groups of PSA normal group and the elevated PSA group (p<0.05). Liver function indicators of y-glutamyltranspeptidase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), aspartate/alanine, albumin, globulin, albumin/globulin were significant differences between the resistance groups (p<0.05). The two groups between degree of fatigue, sitting position working hours, number of weekly exercise and Smoking or not is also a significant difference (P<0.05). The serum PSA levels in Normal weight, overweight and obese group was significant difference (P<0.05). Correlation analysis showed that the serum PSA was positively correlated with age, was weak negatively correlated with creatinine clearance rate (CCR), no correlation with other research factors. Multiple linear regression analysis results showed that the serum PSA level was significantly influenced by age, creatinine and total bilirubin (TBIL). Conclusion The serum PSA level was significantly influenced by age, the MS, the prostate volume, creatinine and total bilirubin. But the correlation between the serum PSA and the MS are not significant in PV normal and low age group object. The serum PSA level with MS and the growth of the number of MS diagnostic indicators of abnormal indicators show a gradual decreasing trend in PV increases group.