Relationship Between Lymphopenia Following The Completion Of R-CHOP Chemotherapy And Relapse In Patients With Diffuse Large B Cell

Objective:This study was to investigate the relationship between absolute lymphocyte count (ALC) following the completion of R-CHOP based chemotherapy and relapse in patients with diffuse large B cell Lymphoma.Methods:60cases come from DLBCL patients diagnosed between2003and2010in Hangzhou first people’s hospital,The median age at the time of diagnosis was60years. All cases have received any cycles of R-CHOP based chemotherapy. Analysed the correlation between ALC at diagnosis and stage, IPI, lactate dehydrogenase. Then compared the ALC following the completion of first-line therapy in early relapse, late relapse group and non relapse group, and estimated it’s predictive value on early relapse in patients with DLBCL.Results:Low ALC at diagnosis was associated with higher IPI risk group.,and elevated lactate dehydrogenase.Among all patients analyzed,9(15.0%) patients were confirmed to exhibit early relapse,7(11.7%) patients late relapse.Patients with early relapsed had a lower ALC[N=9,median ALC=0.8×109/L range(0.25-1.4×109/L)] compared with those without relapse [N=44, median ALC=1.1×109/L, range (0.3-3.7×109/L)]or late relapse [N=7, median ALC=1.1×109/L’rang (0.50-1.9×109/L)] P=(0.009and0.063,respectiveiy). The Positive Predictive Value and negative predictive value of Low ALC were39.1%and81.1%.Conclusion:Low ALC is a poor prognostic marker in patients with DLBCL, Low ALC was associated with lower CR rate by univariate analysis, lymphopenia following the completion of R-CHOP based therapy can be used as a marker to predict early relapse.