140Clinical Analysis Of Drug-induced Liver Injury

Objective: With the continuous development of new drugs in clinical medicine inrecent years, wider application of traditional Chinese medicine and health awareness ofthe growing supply kinds of drugs and clinical application of more and more, inparticular types of non-prescription medicine, traditional Chinese medicine andtraditional Chinese medicine expanded drug in patients with non-prescription drugs,health care or feel free to increase the chances of drug dose increased, the incidence ofdrug-induced liver injury also increased year by year. Discussion on occurrence andcharacteristics of drug-induced liver injury, to provide information on clinical drug safeand effective.Methods: Drug-induced liver injury patients in the men72cases (51.41%),female48cases (48.6%), men and women no significantly differences; average age(48.5±35.5), maximum age for84, minimum age for13; caused liver damage of drugvarieties range, which to Chinese medicine for up to (32.6%), second for antipyreticanalgesia drug (15%), and dermatology medication (12.86%), and Antibiotics (12.14%),;medication two week within appears liver damage patients127cases (90.1%),2-4weekwithin appears liver damage patients1cases (0.7%),4week above appears liverdamage patients2cases (1.43%), cannot provides specific appears liver damage time ofpatients10cases (7.14%); main clinical performance for weak, and is satisfied thatdifference, rash, and itching, nausea, and vomiting, does not apply symptoms, clinicalperformance positive rate for100%; Clinical to liver cell type liver damage mostcommon86cases (61.43%), second for mixed type40cases (28.57%), and bilesedimentation type14cases (10%); clinical cure31cases (22.14%), improves72cases(51.43), is not cure29cases (20.71%), death8cases (5.71%); appears jaundice70cases(50%) is not appears jaundice70cases (50%); appears outbreak sexual liver functionfailure2cases, they are clinical death. Results：Drug-induced liver injury clinical features no special specific, and virussexual, and alcohol sexual hepatitis similar; currently can caused liver damage ofcommon drug can up hundreds of species, to past think comparison security of Chinesemedicine occurs rate high, up32.6%; currently no clear of diagnosis standard, clinicalShang application excluded method for diagnosis, diagnosis more difficulties;Drug-induced liver injury with caused damage Hou for treatment than early prevention:note security medication, and note medication crowd, and timely detection laboratoryindex, and note relative dangerous factors, and timely doctor; Under drug of toxicityand host easy perceptual saw of relationship, can will liver damage is divided into canforecast sexual and not forecast sexual; drug metabolism of reaction form is divided intometabolism activated and fight live, and detoxification; currently poisoning andDrug-induced liver injury of database has been cannot established or sound isDrug-induced liver injury needs solution of problem; the disease cure improves ratehigh, as timely stopped drug or intervention treatment can reached ideal effect; heavysyndrome Drug-induced liver injury patients cases number less, but prognosis poor. Thesaying goes:"All drugs have more or less toxicity " drugs in the treatment of diseases atthe same time, will inevitably give rise to adverse reactions, as medical workers notonly have to understand the use, efficacy, and indication of the drug, its side effectscannot be ignored, so as to better guide the patients, the drug use risk to a minimum,doing the best of a drug.