Effects Of Dexmedetomidine Administered With A Micro Infusion Pump Or Nasal Drops On Endotracheal Intubation During General Anesthesia Induction

Objective：To compare the effects of dexmedetomidine administered with amicro infusion pump or nasal drops on endotracheal intubation during generalanesthesia induction．Methods：60patients （ASA I-II）,who needed thyroid gland surgery,wererandomly assigned to4group （n=15）.0.25ml/kg·h^-1))saline and dexmedetomidine（4ug/ml） were respectively injected with a micro infusion pump in the group A and B;1.0/1.5ug/kg dexmedetomidine was respectively injected with nasal drops in the groupC and D. Endotracheal intubation was placed after dexmedetomidine and saline wereadministered15minutes.Every group were induced with midazolam0.04mg/kg,fentany4μg/kg, etomidate0.3mg/kg, cisatracurium0.2mg/kg. After anaesthesiainduction，tracheal intnhation was performed when the BIS value≤60and it wasmaintained for5s．Anesthesia maintained: After tracheal intubation,1%propofol6-8mg/kg/h continuously infusion pump.The patients were mechanicallyventilated．BP、HR and BIS were recorded before infusion of dexmedetomidine（T₀），at15min after infusion of dexmedetomidine（T₁），before intubation（T₂）,instant timeafter intubation（T₃） and3minute （T₄）,5minute （T₅） after intubation．Results：There was no significant difference in HR and MAP at T₀in the fourgroups （p>0.05）.HR at T₁decreased and MAP increased than that at T₀in the Bgroup（p<0.05）.MAP and HR at T₂increased than that at T₀in the A group（p<0.05）.MAP and HR at T₃-T₄increased than that at T₀in the C group（p<0.05）. MAP and HR atT₂-T₅decreased than that at T₀in the B and Dgroup（p<0.05）.There was no significantdifference in MAP and HR at T₂-T₅in the B、D group. Conclusion: Anesthesia induction by dexmedetomidine administered with a microinfusion pump or nasal drops can be safely used clinical,and hemodynamics is the moststable when1.5ug/kg dexmedetomidineIs administered with nasal drops, the same as a micro infusion pump,1.5ug/kgdexmedetomidine nasal drops can be recommended as the best dose for clinical use.