Animal Studies Of Hyperbaric Oxygen Treatment Of Traumatic Brain Injury Time Window

There have many years history treating for traumatic brain injury by Hyperbaric oxygenand the effect of treatment has been widely accepted by clinicians. However, the most typesof HBO treatment have not definite effect time window in domestic, and it is lack ofsufficient evidence only by clinical experience for treatment to observe the clinical curativeeffect. On the other hand, there have only a few reports about the academic research of thetime window of HBO treatment. This study aims to be useful in clinical work and discuss thebest method of HBO treatment by the treatment of craniocerebral injury using SD rat animalmodel of experimental research.Objective: The aim of our study is to observe the effect that the change of hyperbaric oxygentherapy (HBO) time has been done in the recovery of the SD Rats’ neurologic function andmyodynamia status, in order to obtain the more effective therapeutic time. Methods: Ninetyhealthy male SD rats weighing at220-250g (provided by the Experimental Animal Center)were examined. All subjects were randomly divided into6groups: the pseudo-operationgroup (N=10), the control group (N=10), the3h post-traumatic group (N=10), the6hpost-traumatic group (N=10), the12h post-traumatic group (N=10), and the24hpost-traumatic group (N=10). The same number of rats will be chosen for ccomplement ifsome of them died.All above treatment groups received the hyperbaric oxygen therapy atdifferent time. And then we will observe the condition of in the recovery of SD Rats’equilibrium function and myodynamia.Results: During the therapy of HBO, the balancefunction of the rats were got more improve in the3h and6h post-traumatic group than the12h and24h post-traumatic group; Comparing to the control group, the24h post-traumaticgroup got less effective and had no statistical significance.The P value of the3hpost-traumatic group and the6h post-traumatic group is less than0.01,however, the24hpost-traumatic group’s P<0.05is considered no statistically significant.Conclusion: The treatment of HBO in the3h and6h post-traumatic in rats get much more effective than the12h and24h groups.