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Meta-analysis For The Efficacy Of Statins In The Treatment Of Polycystic Ovary Syndrome

Posted on:2014-05-17Degree:MasterType:Thesis
Country:ChinaCandidate:X H LiFull Text:PDF
GTID:2254330392967244Subject:Obstetrics and gynecology
Abstract/Summary:PDF Full Text Request
[Objective] To assess the efficacy of Statins in the treatment of polycystic ovarysyndrome,then provide relevant suggestions for the clinical treatment.[Methods]The Cochrane systematic review method was used to evaluate theRandomized Controlled Trials(RCTs) of Statins in the treatment of PCOS. Thesearching strategy included:MEDLINE(1950to04.2013),EMBASE(1980to04.2013),The Cochrane Central Register of Controlled Trials,Current ControlledTrials,The National Research Register,Clinical Trials,CBM(1978-2013.04),VIP(1989to2013.04),CNKI(1996to2013.04).We also manual searched somerelated journals.The search has been conducted till04.2013.Three reviewersevaluated the quality of studies,and meta-analysis were performed to combine theresults of homogeneous studies.The RevMan5.0software was used for statisticalanalysis.[Results]We recruited3studies with331patients enrolled.All included studiesused Statins in the treatment of PCOS comparing with placebo, or statins combinedwith other drugs(oral contraceptives, metformin) treatment compared with otherdrugs monotherapy. Patients in the control group received placebo or othermonotherapies,and patients in the experimental group received Statins therapy orStatins combined with other drugs. All the included studies described randomizationand concealment of allocation, while some studies did not use the blind method.We conduct analysis by measurement and intervention measures.Meta-analysis basedon included studies showed that the statins group was more effective in reducing BMI,total testosterone, total cholesterol, triglyceride, low density lipoprotein, fastinginsulin and hsCRP,while there were no significant change in LDL and FBG. But different degrees of heterogeneity can be observed in some groups of research in themeta analysis.[Conclusion]The evidence from this paper showed that Statins therapy alone orcombined with metformin、oral contraceptives can reduce the body mass index, totaltestosterone for PCOS patients;Statins therapy alone or combined with metformin caneffectively reduce TC、 TG、 LDL,but had no obvious effect on HDL;Statinmonotherapy can effectively reduce hs-CRP;We can not yet confirmed that Statinshave advantage in improving insulin resistance compared with metformin.Insummary,Statins can effectively reduce BMI, testosterone, lipids and inflammatorymarkers of patients with PCOS, so as to provide protection for cardiac and cerebralvessels.
Keywords/Search Tags:Polycystic ovary syndrome, Statins, system evaluation
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