Prognostic Significance Of Mcl1Cdkl In Advanced Non-small Cell Lung Cancer Patients

ObjectiveTo detecting the Prognostic Significance of apoptosis pathway proteins Mcll and cyclin-dependent kinase Cdkl in patients with advanced non small cell lung cancerMethodsConsecutive patients with pathological stage III and IV squamous cell carcinoma (SCC) or adenocarcinoma (ADC) were enrolled retrospectively from Xijing hospitals.Patients who received multidisciplinary treatment modalities and standard supportive care between March2008and June2012were qualified for this study.We used IHC analysis to determine the expression levels of Mcll protein and Cdkl in specimens of advanced non-small-cell lung cancer. Patient cumulative survival was analyzed by the Kaplan-Meier method and cumulative survival differences were determined by log-rank test and a Cox regression model adjusted for clinical and pathological factors. ResultsThe144patients included64cases of squamous cell carcinoma,69cases of adenocarcinoma and11other cases. The pathological TNM stages of the patients were stage III (45patients,31.25%) and stage IV (99patients,68.75%). Sixty-four (44.44%) patients were observed with high expression levels of Mcll and80(55.56%) with low expression levels of Mcll. The univariate analysis by log-rank test showed that pathological TNM stage was a significant prognostic factor. The1-year survival rates of patients were74.20%for stage III (median survival days:666) and55.60%for stage IV (median survival days:415)(p=0.033). The univariate analysis by log-rank test showed that Mcll expression had prognostic significance (p=0.042). The1-year survival rates of patients were69.90%for Mcll high expression (median survival days:612) and55.30%for Mcll low expression (median survival days:406); this difference was statistically significant (p=0.042). The Cox regression analysis showed that both the expression of Mcll(OR=1.809,95%CI (1.123-2.912), p=0.015)å’ŒTNM stage(OR=0.573,95%CI (0.336-0.978), p=0.041) were independent prognostic factors. The univariate analysis by log-rank test showed that TNM stage(p=0.033) and Cdkl had prognostic significance (p=0.015),The1-year survival rates of patients were44.44%for Cdkl high expression (median survival days:339) and55.56%for Cdkl low expression (median survival days:552); this difference was statistically significant (p=0.015). The Cox regression analysis showed that both the expression of CDK1(OR=0.624,95%CI (0.400-0.973), p=0.038) and TNM stage (OR=0.515,95%CI (0.297-0.894), p=0.018) were independent prognostic factors.ConclusionsThis study indicates that Mcll,Cdkl protein and Pathological TNM stage both independent prognostic factor for advanced NSCLC. High expression Mcll tumors appear to correlate with better prognosis than low expression Mcll tumors in advanced NSCLC patients whlie Low expression of Cdkl tumors appear to correlate with better prognosis than high expression Cdkl tumors in advanced NSCLC patients, stage III had a better prognosis than those of stage IV.