Flurbiprofen Ester Compound Opioid In Gynecological Laparotomy Postoperative Analgesia

Purpose:The observed the flurbiprofen axetil composite opioids for controlled analgesiaafter gynecological laparotomy clinical efficiency Fruit and comparative study.Method: Select Yan’an University Affiliated Hospital gynecological surgery in May2012-2012in October, Age of40to60years old, weighing45~~75kg, ASAclassification Ⅰ~Ⅱ undergoing elective abdominal surgery90patientsRandomlydivided into three groups, Butorphanol group (B, n=30), sustained amount:butorphanol6mg+flurbiprofen axetil The90mg+tropisetron6mg to100ml, loadamount: butorphanol1mg to5ml; Morphine group (M group, n=30),Sustained amount:morphine30mg+flurbiprofen axetil90mg+tropisetron6mg to100ml, morphine5mgloading dose:To5ml; The flurbiprofen axetil group (F group, n=30), sustainedamount: flurbiprofen axetil120mg+tropisetron6mg To100ml, loading dose: theflurbiprofen axetil50mg to5ml. All patients not to preoperative medicine, into theoperating room When, after the establishment of intravenous access, monitoring ofblood pressure, heart rate, breathing, blood oxygen saturation. Block anesthesia beforethe start of Each patient were given a balanced salt500ml, All patients with spinal-epidural anesthesia, take the left Supine, select waist-waist gap, routine disinfectionshop towels, first local infiltration with1%lidocaine Ma Drunk, then18G epiduralneedle puncture, there is a sense of frustration for the negative pressure test, determinedto enter the epidural Spinal needle is then placed in the chamber, depending on thepatient’s height lumbar anesthetic (lumbar anesthetic compatibility:0.75%bupivacaine1.8ml+50%glucose0.2ml+CSF3ml)15seconds into the inferior vena push spider filmspeed, Exit the spinal needle, epidural catheter was inserted and secured to the head.The disposable medication, surgery long time need Additional drugs not included in theexperiment, anesthesia control in the chest following.30minutes before the end of surgery Loading dose, then analgesia pump, observed blood loss, the end of surgery, allpatients were sent back to the intensive care unit, observation10minutes to20minutes,the respiratory and circulatory system is stable, and then sent back to the ward.Observed every5minutes after injection and The records the HR, BP, RR and sPO2.6,12,24and48hours after surgery to monitor HR, BP, RR and sPO2,6,12,24and48hours respectively after record pain scores (VAS score), PCA pressing times ratedAdverse reactions of nausea and vomiting score, pruritus score and respiratorydepression.Result:1. Three groups of the patient’s age, weight, ASA physical status, blood loss,length of operation time None Significant difference.2. The analgesic rated using a visual analog scale (VAS score):6,12,24and48hours after the butorphanol group (B) and morphine group (M) and flurbiprofenaxetil group (F) significant difference (P <0.05), butorphanol group (B) and theanalgesic effect of morphine group (M) is superior to the flurbiprofen axetil group (F).Butorphanol group (B) and the analgesic effect of morphine group (M) no significantdifference (P>0.05).3. PCA pressing times of the three groups of patients: butorphanol group (B)and morphine group (M) was significantly lower than the flurbiprofen axetil group (F)(P <0.05), butorphanol group (B group) and morphine group (M) showed nosignificant difference (P>0.05).4. Nausea and vomiting Rating: butorphanol group (B) and flurbiprofen axetilgroup (F), significantly lower than morphine group (M)(P <0.05), butorphanol (Bgroup) and fluorine axetil group (F) There was no significant difference (P>0.05).5. The itching score: butorphanol group (B) and flurbiprofen axetil group (F),significantly lower than morphine group (M)(P <0.05), butorphanol group (B), andfluorine than the ibuprofen ester group (F) there was no significant difference (P>0.05).6. Adverse reaction: butorphanol group (B) and flurbiprofen axetil group (F),postoperative drowsiness, respiratory depression was significantly lower than morphinegroup (M)(P <0.05), the difference was statistically significance. Conclusion: Exact butorphanol flurbiprofen axetil for gynecological laparotomypostoperative analgesic effect, nausea, vomiting, skin itching, respiratory depression, alow incidence of side effects, and more suitable for gynecological laparotomypostoperative intravenous analgesia.