Retrospective Analysis On The Clinical Characteristics Of1882Cases Of Breast Cancer During The10Years And The Treatment And Trends

Objective Explore the the Ningxia region breast cancer clinical features,pathological features, diagnosis and treatment mode trend for the clinic leveland the status quo of the Ningxia region, to provide a scientific basis toimprove the diagnosis and treatment of breast cancer standardized.Methods Retrospective review and analysis of the clinical data of1882cases of breast cancer patients,which were treated from January2002toDecember2011in the General Hospital of Ningxia Medical characteristics.Employing SPSS11.0statistical software for statistical analysis of the data.Results1882cases of breast cancer diagnosis and treatment in10years,the number of cases has increased year by year, the average age is of48.94±10.87years old, with a median age of47-year-old,45-49-year-old peak ageof onset. Han majority in all cases accounted for86.4%, accounting for11.4%of the Hui Hui upward trend in the proportion of patients with breastcancer. Early breast cancer (≤Ⅱ a period) and advanced breast cancergroup (≥Ⅱ b period) There were significant differences in the patient’soccupation, breastfeeding history, malignant family history, and menopausalstatus. Upper outer and inner upper quadrant is the most common site ofbreast cancer. B-ultrasound is the initial visits of the most important means ofchecking, and the highest proportion (56.6%), is followed by mammography(20.7%) and MRI (15.8%).B-10-year breast mammography, MRI examination proportion was in gradually rising trend. Intraoperative frozenpathological examination is still the main way of biopsy (49.9%), theproportion of core needle has been significantly increasing year by year.Invasive ductal carcinoma of the breast is the most common pathologicaltype (86.3%).≤Ⅱa period the number of cases is rising≥Ⅱb period thenumber of cases is a downward trend in the past five years (2007-2011)≤PhaseⅡaproportion of cases(64.1%)was significantly greater than≥Ⅱbperiod (35.8%). Tumor size T staging T1ratio gradually increased, T2, T3has been constantly decreasing substantially; T4. Surgical dissection ofaxillary lymph node number of10patients are gradually increasing, withoutlymph node metastasis (N0) patients (53.8%), and presnts an increasing trend.Estrogen and progesterone receptor (ER, PR) detection has been increasingyear by year, the proportion of ER+PR+highest proportion (56.3%).C-erbB-2(HER-2) Check that the proportion showed an increasing trend,HER-2(-)proportion of patients is with an upward trend. The moleculartyping LuminalA type is of the highest proportion (53.5%),which is followedby the Basal-like type (18.3%), LuminalB type (17.5%),HER2(+)-type(10.7%).10years LuminalA type downward trend upward trend,LuminalB, HER2(+)type the Basal-like type is basically unchanged. Majorsurgery for breast cancer patients10years for a modified radical mastectomy(86.5%), and gradually increase the proportion of breast-conserving surgery(increased from4%to9.1%). Postoperative adjuvant chemotherapyconstituent ratio is of87.7%, in a declining trend, neoadjuvant chemotherapyconstituent ratio of12.3%, showed an increasing trend. The modified radicalpostoperative radiotherapy (29.6%), postoperative radiotherapy preservingmilk is in upward trend. Postoperative adjuvant endocrine therapy the major endocrine therapy (50.8%), and there’s no significant trend (P>0.05)between the10-year downward trend, the endocrine drug selection,tamoxifen, aromatase inhibitors applications proportion. The upward trend.Targeted drug therapy in the treatment of breast cancer in the proportion isstill lower,10-112(3%).Conclusion There is an increasing trend in the number of breast cancerduring the10years on governance, the median age of onset is of47years old,the age of onset of breast cancer is more than1/3(37.1%) of the4049-year-old. Advanced breast cancer group (≥Ⅱ b of) mentalbreastfeeding were diagnosed with early stage breast cancer (≤Ⅱ aperiod),which is is higher than the proportion of manual workers, nobreastfeeding in the two groups in the distribution happens opposite. Breast Bultrasound, mammography, MRI, showed an increasing trend in theproportion of core needle≤Ⅱ a period of patients with breast cancershowed an increasing trend. Breast-conserving surgery, neoadjuvantchemotherapy, application of endocrine therapy with letrozole showed anincreasing trend, while targeted therapy is still rarely carried out.