Study On The Preparation And Application Of Silver-carried Zirconium Phosphonate

With the development of the society and the improvement of living standards, people show more and more concerns for the quality of life. However, diseases caused by bacterial are still common in our daily life which seriously endangering people’s health. Traditional antibacterial agents showed all kinds of problems in the process of long-term use, such as:fast dissolution and antibacterial validity period is shorter, poor weatherability, easy to change color, easy to reunite, and larger irritation to the skin, antibacterial spectrum is narrow, long-term use can also lead to the emergence of resistant strains. Combining the advantages of traditional antibacterial agents, we prepared inorganic/organic composite antibacterial agents to achieve the better antibacterial effect. In order to overcome these shortcomings, we synthesized zirconium phosphonates and silver carried zirconium phosphonates with the organic functional groups by surface functionalization. We carried out the works as follows:(1) Silver nanoparticles (Ag NPs)-carried zirconium p-benzoic acid-N, N-dimethylenephosphonate (Ag-ZPABDPA) was successfully synthesized, and its potential application as synergistic antibacterial material was investigated. Ag NPs, with diameter of30nm, were anchored tightly onto ZPABDPA, with the emplacement of the Ag NPs on the ZPABDPA increasing the antibacterial activity of the Ag NPs through diminution in the extent of nanoparticle aggregation. Due to the synergistic antibacterial effect of the Ag and ZPABDPA, the Ag-ZPABDPA showed a better antibacterial activity than Ag and ZPABDPA with a minimal inhibition concentration (MIC) of16and0.5μg mL-1against Escherichia coil and Staphylococcus aureus, respectively. Also, this silver-carried zirconium phosphonate did not show any cytotoxicity against mammalian cells (A549cells) even at a concentration above the MIC (256μg mL-1). Thermogravimetric analysis (TGA) proved that the ZPABDPA was quite stable under thermal conditions. Collectively, these properties make the newly synthesized silver-carried zirconium phosphonate potentially superior disinfectants and antiseptics for various biomedical and biotechnological applications.(2) Four novel silver-carried zirconium phosphonates with different organic chain were synthesized. The prepared products were evaluated for their antibacterial activities against Gram-positive bacteria (S. aureus ATCC25923) and Gram-negative bacteria (E. coli JM109), to explore the effects of organic chain length on the antibacterial activity. The products were characterized by Fourier transform infrared (FT-IR) spectroscopy, wide-angle X-ray diffraction (XRD), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC). The results showed that the different organic chain length of silver-carried zirconium phosphonates can affect the antibacterial activity. As expected, the antibacterial activity were improved with the increasing of organic chain length of silver-carried zirconium phosphonates. This is mainly duo to the longer the organic chain, the stronger the hydrophobic the material surface, enhancing the adsorption between the material and the bacteria.(3) In this work, we used silver nanoparticles (Ag NPs)-carried zirconium p-benzoic acid-N,N-dimethylenephosphonate (Ag-ZPABDPA) and Silver-carried zirconium (glycine-N N-dimethylenephosphonate)(Ag-ZGDMPP) nanoparticles as the antibacterial nanomaterials. Selected chitosan and oxidized starch as the carrier to prepare chitosan/silver-zirconium phosphonates (CS/Ag-ZPABDPA) and oxidized starch/Silver-carried zirconium (glycine-N,N-dimethylenephosphonate)(OST/Ag-ZGDMPP) composite film. The mechanical properties, the water resistance performance, antibacterial activity and the structure of the composite film were changed with the adding amount of Ag-ZPABDPA, ZPABDPA, Ag-ZGDMPP and ZGDMPP. The results showed that because of the addition of Ag-ZPABDPA, the antibacterial activities of composite film against Escherichia coli and Staphylococcus aureus were significantly enhanced. And the mechanical properties and water resistance performance of CS/Ag-ZPABDPA-n and OST/Ag-ZGDMPP nanocomposites were improved. Our findings reveal that Ag-ZPABDPA nanoparticles can not only improve the antibacterial properties of film packaging material, but also can improve the mechanical properties of composite materials.