Based On Qi And Yin Deficiency, Blood Stasis Turbidity Resistance And Pathogenesis Of Diabetic Nephropathy Syndrome Clinical Studies

Objective:Take a cross-sectional survey to compare and analyse the compos ing and characters of Qiyinliangxu, Tanzhuoneizu of the diabetic nephropath y in traditional Chinese Medicine.We believe that the analysis of a certain t ype of evidence pathogenesis evolution of diabetic nephropathy can help us explore the dynamic changes of whole dynamic changes syndromes,searching the pathogenesis of this disease evolutionMethods:According to researching "Nephrology" and’The diagnosis of dia betic nephropathy syndrome and therapeutic evaluation standards, types of s yndrome differentiation and assessment standards of Chinese Medicine. Firstl y,the survey includes diabetic nephropathy stage III and stage IV patients w ith130cases in the standards-compliant and record their common clinical manifestations. Secondly, rate different grades of the patients based on the1evels of symptoms and record the biochemical indicator.Process the data wi th cluster analysis.The database were founded and processed SPSS19.0statis tical software. We analysis the description of the data and search the differ ence between symptoms, correlation with biochemical indicators, exploring t he dynamic changes of diabetic nephropathy syndrome in traditional Chinese Medicine.Results:1.The subjects were included in the cases of130cases, male62cases, fem ale68cases, male to female ratio is0.9.The range of age is from28to70and the mean is58.49±9.11,which the DNIII patients’mean is59.27±7.53and DNIV is57.67±10.53.2.frequency in order from high to low arrangement is languid, fatigue, nu mbness, blurred vision, dizziness, palpitations, shortness of breath, thi rsty,symptoms limb edema and so on Compare the frequency of individual symptoms in which each installment, dizziness, limb edema, blurred visi on and other symptoms by chi-square test shows a significant difference (P <0.05) on the frequency in each of the emergence of DN. frequency of DN III in order from high and low symptoms infatigue, numbness, blurred v ision, dry mouth, want to drink, dizziness, palpitations, shortness of breath, five upset hot, tinnitus, looking Shaohua and limb edema. DN IV appear fatigue, blurred vision, numbness, dizziness, palpitations, s hortness of breath, dry mouth To drink, five upset hot, bad looking,limb edema and tinnitus. 3.According with the TCM designate the severity grading score to score IV period than any single symptom score higher stage Ⅲ Overall, total sympto m score IV is higher than Ⅲ. Symptoms of blurred vision, looking Shaohu a, a significant difference between Ⅲ and IV period(P<0.05), symptoms s uch as dizziness, numbness, limb edema is a statistically significant diffe rence between Ⅲ and IV period (P<0.01), total symptom score between sta ge Ⅲ and IV stage with a statistically significant difference (P<0.01).4.The data of TCM symptom is processed with cluster analysis. Combine with the statistical computing expertise and divide into four categories certif icate type. First class syndrome type for Qixu type; the second class syndro me type for Yinxu type; the third class syndrome type kidney deficiency; fo urth category of blood stasis syndrome type type.5.The most common type is XueYu, Yinxu, Qixu and ShenXu least. The var ious installments syndromes distribution is consistence with the whole syndr ome. There is a significant difference between Ⅲ and IV period in XueYu (P<0.05).6.With the comparison of four types in TCM,we know that the score of IVi is higher than Ⅲ.There is a significant differences between ShenXu and XueYu (p<0.01), no significant difference in YinXu and Qixu type.7.According to the correlation between syndrome and biochemical indicator s, we know that UACR significantly correlates with Dizziness, numbness, li mb edema, blurred vision and other symptoms and their correlation (P<0.05). Blurred vision significantly correlates with GFR,Scr,BUN(P<0.05).8.According to the correlation between types of TCM and indicators, there i s no significant difference. ShenXu correalates significantly with UACR(p<0.05) and24hUAE (P=0.056).There is significant difference between XueYu and biochemical indicators.Conclusion:l.With the progression of the disease from the Phase Ⅲ gradually progress to the stage Ⅳ, syndrome of ShenXu and xueyu gradually increased, The x ueyu type proportion aggravated.2. There is a correlation between shenxu type and xueyu type with biochem ical indicators UACR. Xueyu type may relate to GFR.