Meridians Preparetions Of Alpha Asarone Long-term Research Of In Situ Gel

Objective Looking for a better treatment of asthma points to medicine preparetions system by further research.Method This paper summarizes the inquires the sure model drugs through a large number of data; Studty model drug and the dissolution of the carrier material properties through the before prescribing research; Establish in vitro release content determination methods and determination method of drug in situ gel; The prescription was optimized by orthogonal designing method based on the single factor investigation; Study the mechanism of drug release in situ gel in vitro through the model fitting; Through the preliminary stability research to identify preparation and storage conditions of preparation; Investigation in situ gel in the body and degradation of the state by the study on the lifetime of the gel in the hypodermic of mouse; The rat capillary row phlegm method and the eggs innocent of rats caused by protein asthma intervention to study the in situ gel meridians implanted preliminary efficacy.Result a-asarone as model drug and PLGA was chosen as carrier material; High performance liquid chromatography (HPLC) method was developed for in vitro assay of drug content and the release rate of drμg in-situ-gel; An acupoint implanted in situ gel containing9%asarone,25%PLGA(75:25, η=0.26),10%PEG400,64%NMP was made; The drμgs in situ gel could release for20days, the release test disclosed that the release of drμg from the formulation belonged to Weibull diffusion; The research results of stability showed that the product was stable in low temperatures and dark place; The gel can stay at25days from the study on the lifetime of the gel in the hypodermic of mouse; The effect of asthmatic rats’s between implant gel and catgut implantation at acupoint was studied, α-asarone in-situ-gel could alleviate the sympoms of asthma to some degree.Conclusion In the study we make a better injection in situ gel which is convenient for injection, curing with good performance in vitro release, slow, even ashdod, only Smaller sudden release. The in situ gel was implanted in danzhong, kidney and pulmonary acu-points feishu in rats can accelerate the excretion of rat sputum,and a-asarone in-situ-gel could alleviate the sympoms of asthma to some degree.