Mild Cognitive Impairment In Patients With Tcm Syndrome Characteristics And Its Correlation With Painting Clock Test Scores

Objective:To explore the role of clock drawing test as a neuropsychological screening tool for mild cognitive impairment (MCI), Chinese Medicine syndrome characteristics of MCI, and the correlation between the score of CDT and the syndromes.Methods:There were486subjects from Dongzhimen Hospital and seven communities. All subjects were divided into three groups according to their cognitive status, assessed by comprehensive neuropsychological assessments:Normal Cognition subjects (NC), MCI patients and mild AD patients. Then analyze the data by canned software SPSS18.0.Results:Receiver Operating Characteristic curve (ROC curve), which is applied to evaluate sensitivity and specificity of the CDT, analysis results:area under the curve of CDT is0.503, the sensitive is79.7%and a specificity is10.7%. CDT score:NC group (3.75±0.55)> MCI group (3.96±0.25)> mi Id AD group (2.41±1.34, P=0.000), there were significant differences (P<0.01). CDT and the relationship between other syndromes:CDT and MMSE was a positive correlation (r=0.640, P<0.01) was negatively correlated (r=-0.651, P<0.01) and ADL. The CDT impact of factors:the CDT score and age was negatively correlated (-0.178), and level of education was positively correlated (0.245) MCI group syndromes in descending order of frequency:Static blood obstructing brain (37.34%), Deficiency of kidney essence (34.18%), Syndrome of phlegm (33.54%), Hyperactivity of yang due to yin deficiency (25.95%), Deficiency of blood and qi (6.96%), Excess of toxic heat (1.9%), Viscera stagnation and turbid left (1.9%). Logistic regression results show that:Static blood obstructing brain and Syndrome of phlegm is risk factors of MCI, Syndrome of phlegm is risk factor for MCI conversion to mild AD; Syndrome of phlegm upper orifices or the implementation of the dysfunction of the risk factors. Correlation between the CDT score syndromes:the phlegm Mongolia orifices CDT score was negatively correlated, the correlation coefficient r=-0.214(P=0.000).Conclusion:1. The specificity and sensitivity of the CDT is too low to be applied to MCI screening alone.%ith the MMSE, ADL was significantly related, and less affected by the level of education, screening for MCI and MCI patients cognitive function was evaluated with the MMSE and the ADL Joint. 2. MCI common syndrome:Stagnation brain network, Deficiency of kidney essence, Static blood obstructing brain. Syndrome of phlegm is the syndrome characteristics in MCI, which the phlegm Mongolia awakened card through the important risk factors for MCI, its existence and further development of MCI to mild AD, and the executive function of patients by The loss is also closely related.