Objective:To observe the AMD Chaihu Shugan Powder with traditional decoction of chronic superficial gastritis (hepatogastric not type) of the therapeutic effects of agents and traditional decoction AMD dose-effect relationship for the comparative study, a clear Chinese medicine treatment chronic superficial gastritis (hepatogastric not type) prescriptions, dosage form and dose of Choice law, and improve chronic superficial gastritis in patients with therapeutic effects, reducing dosage and save the Chinese herbal medicines were of great significance.Methods:A randomized, double-blind, parallel-positive control drug experiment design method. By blind requirements, will be 60 cases of Digestion branch patient or out-patient diagnosed as chronic superficial gastritis and TCM for hepatogastric not qualified subjects and patients, to the ratio of 1:1 were randomly assigned to treatment group and control group; treatment group of patients with AMD Chaihu Shugan Powder (1/3 the volume of traditional decoction prescription); control group patients with traditional Bupleurum Decoction Powder. In both groups a day, a one package, taking temperature for half an hour before eating, serving every day twice, taking a total of 15 days. Reference to "Chinese medicine clinical research guiding principles" standard to determine the clinical symptoms and signs graded quantitative criteria, recording each patient before and after treatment of symptoms of TCM quantitative requirements of points to do before and after treatment gastroscopy, Helicobacter pylori inspection, pathological examination, the security index examination:including blood, urine, faeces three conventional, liver function (ALT), renal function (BUN. Cr) and ECG General after the end of treatment evaluation, comparison groups and group treatment before and after the effect of indicators (TCM symptoms and signs requirements, gastroscopy, biopsy, HP check) changes, combined with the various safety indicators observed in each group of treatment efficacy and safety evaluation. Statistical Analysis.Results:1. The treatment of a course of treatment, the treatment group,3 cases recovered,10 cases markedly effective, effective 13 cases, four cases of invalidity, the total effective rate was 86.7%; control group, two cases of cured,8 cases markedly effective, effective 15 cases,5 cases of invalid, The total effective rate was 83.3%. After statistical analysis, clinical efficacy between the two groups (including the requirements of TCM symptomsand signs, gastroscopy, biopsy, HP checking), the total effective rate, markedly effective rate were no significant difference (P> 0.05), prompt treatment group and control group General efficacy considerable.2, medication, the treatment group of drug onset time than the control group (P> 0.01) 3. After treatment, symptoms, signs total score) compared with pre-treatment significantly reduced (P<0.05); the control group after treatment symptoms, signs and the total score before treatment less than significant(P<0.05); the treatment group before and after treatment symptoms, signs total score difference comparison There was no significant difference (P>0.05) were significantly tips the effect of two drugs, and two considerable effect.4. Gastroscopy hyperemia, edema, the inflammatory pathological grading, HP to check the situation of negative effects:treatment group and control group before and after treatment compared themselves were significantly different (P<0.05); and the treatment group and control group effects after treatment compared with no significant difference (P>0.05). also prompted the two drugs have shown the effect of treatment, and similar efficacy between the two.5. two groups of patients before and after the blood, urine, faeces of conventional liver function (ALT), renal function (BUN. Cr) and ECG were normal. The observation process, the two obvious adverse reactions were found.Conclusion:Advanced Micro Devices Chaihu Shugan Powder TCM treatment for hepatogastric not and type of chronic superficial gastritis, at General efficacy, the improvement of symptoms, endoscopy, pathology, HP negative, etc. with traditional Chaihu Powder considerable effect, the precise short-term efficacy and found no adverse reactions. Description Supermicro Chaihu Shugan Powder is a better clinical efficacy and safety of traditional Chinese medicine preparations. |