Investigation Of The Relationship Between Metabolic Syndrome And C-reactive Protein(CRP) And Type2Diabetic Retinopathy

ObjectiveDiscuss in type2diabetes c-reactive protein (CRP) and metabolic syndrome eachindex （Hyperlipidemia, hypertension, and obesity）and diabetic retinopathy (DR)relationship. Study CRP level and metabolic syndrome each index（Hyperlipidemia,hypertension, and obesity）and diabetes without retinopathy group, non proliferationperiod (mild, moderate, and severe), breeding period (PDR) diabetic retinopathygroup whether there is difference between group, and c-reaction protein and metabolicsyndrome can each index（Hyperlipidemia, hypertension, and obesity）is type2diabetes and DRof the genesis and development of risk factors in patients with type2diabetes, in a certain extent happen DR, DR the risk of serious degree have predictivevalue.Objects and methodsAccording to the1999World Health Organization (WHO) diabetes diagnosisstandard, selected in April2011to September2012during the176patientshospitalized in the Department of endocrinology of China-Japan Union Hospital ofJilin University for treatment of T2DM patients, including male96cases, female80cases, age (34-80)years old, average age (59.36±10.48) years old. DM diagnosisstandard reference1999WHO make the criteria for the diagnosis of diabetes:①Hasthe typical symptoms of diabetes, any time of blood glucose value>11.1mmol/L(200mg/dl);②No typical symptoms, only fast eight-twelvehours of fasting plasmaglucose (FPG)>7.0mmol/L(126mg/dl);③Glucose tolerance test2hours plasmaglucose value>11.1mmol/L (200mg/dl); The above three any a up to standard canbe diagnosed with diabetes. Exclude type1DM, secondary DM, DM acutecomplications, liver and kidney dysfunction, rheumatism immune disease, tumor history, one month operation history, pregnancy and lactation women.Retrospective analysis using statistical research. According to the conditions ofthe selected176patients with T2DM patients, blood samples are from into theresearch object fast after10hours after the next morning venous blood, byendocrinology doctor does fundus camera inspection or the oculist line fundusprocuratorial. According to the2002international classification standard【1】it isdivided into five stages: no significant retinopathy (1period), mild not fertile diabeticretinopathy (2period), moderate not fertile diabetic retinopathy (3period), severe notfertile diabetic retinopathy (4period), fertile diabetic retinopathy disease (5period).According to the degree of fundus lesions in the research object will be divided intotwo groups: DR group (T2DM merger retinopathy group) and97cases of controlgroup (T2DM unconsolidated retinopathy group) in79cases. The two group of c-reactive protein, HbAlc,the total prevalence of MS and MS components such as SBP(systolic pressure), DBP, diastolic blood pressure), BMI，TG (triglyceride), TCH(total cholesterol, HDL-c (high density lipoprotein cholesterol), LDL-c (low densitylipoprotein cholesterol) index to compare, analysis of the above substances DRperiods of change, at the same time application Logistic regression analysis researchDR happen related factors. P <0.05said have statistical significance.Result1. The selected object, diabetes without retinopathy group (control group)c-reaction protein, the overall prevalence of MS HbAlc level espectively (2.13and1.19mg/L,(8.6and1.4)%,48.1%(38/79) were significant differences, diabeticsretinopathy group (DR group) were (2.95and1.93mg/L,(9.9and2.0)%,63.4%(62/97), the control group and DR group more significant difference (P <0.05).2. Between the two groups in terms of SBP, DBP, BMI, HDL-C, LDL-C, FPGindices such as the differences between the two groups were no statistical significance(P>0.05), indicating that the occurrence of diabetes microvascular lesions are notaffected by the influence of these indicators.3. DR group of serum TC and TG level are higher than those in the control group,the difference is statistically significant meaning (P <0.05)，DR and TG, TC related。 4.DR group MS four single the prevalence of risk factors are higher than those inthe control group, but between the two groups have significant difference only highblood pressure (P <0.05).5.DR group HbAlc level,c-reaction protein levels were significantly higher thanthat of diabetes without retinopathy group, significant difference; Diabetic retinopathygroup of each phase of a reaction between C protein levels have significant difference(P <0.05), there is statistical significance, diabetic retinopathy level andc-reactionprotein levels were positively correlated, and HbAlc level andc-reaction proteinlevels were positively related to sex (P <0.05), there is statistical significance.6. DR risk factors of the Logistic regression analysis showed that the course，CRP and TG is DR happen risk factors (P <0.05).Conclusion1. C-reactive protein levels were significantly higher in the DR group，And1-5stage diabetic retinopathy group increased gradually,c-reaction protein level maybe DR cytokine mediated inflammatory reaction.2.Type2diabetes mellitus patients with MS retinopathy theprevalence、 high blood lipid、 hypertension. metabolic syndrome risk factors highcholesterol and high blood pressure in patients with type2diabetes with be happenedretinopathy risk factors.3. CRP、Blood pressure, cholesterol to diabetic retinopathy and the risk of theserious degree of predictive value.