Meta Analysis Of The Residual Or Recurrent High Risk Factors Of High Grade Cervical Intraepithelial Neoplasia After Conization

Cervical intraepithelial neoplasia (CIN) is the precancerous lesionwhich is closely related to cervical carcinoma and divided into3gradesaccording to cellular atypia. CIN Ⅱ and CIN Ⅲ are known as high gradeintraepithelial neoplasia, whose occurrence and development haveintensely connected to high risk human papilomavirus (HR-HPV)infection.So far,both native or foreign scholars choose conization to bethe first choice of treating CIN. However,the rate of treatment failurewhich always occurs in the2years is from1%to25%.The recurrenceof CIN Ⅲ is relatively more obvious. Therefore,the evaluation of therecurrent or residual high risk factors after conization is more valuableand indispensible.Objectives:To comprehensively evaluate the residual or recurrent high riskfactors of high grade cervical intraepithelial neoplasia after conizationwith the help of Meta analysis.Methods:Search the database such as Pubmed database, Medline database,Elsevier database, CNKI website, WanFang website, VIP website about theresidual or recurrent high risk factors of high grade cervicalintraepithelial neoplasia after conization. All the data were analyzedby Revman5.2software.Results:16case-control studies about the high risk factors of the residual or recurrent disease of high grade cervical intraepithelial neoplasiaafter conization according to the include criteria and the excludecriteria were assessed. The cumulative cases and controls were490and2532respectively.Meta analysis results were that the residual orrecurrent rate of the group such as menopause，age more than50years，involving the glands, positive margin，HR-HPV amount more than1000RLUbefore conization，ECC positive before conization，HR-HPV infection after6months were higher than the control group.Conclusion:menopause，age more than50years，involving the glands, positivemargin, HPV amount more than1000RLU before conization，ECC positivebefore conization,HPV infection after6months are all the residual orrecurrent high risk factors of high grade cervical intraepithelialneoplasia after conization.