Electrophysiological Network Modeling Of Glomerular And Study Of Plateau Potential Periglomerular Cells

As the first synaptic relay center in olfactory system, olfactory bulb is an important part in integrating and coding the olfactory information. Thus, the research of the electrophysiology of the olfactory bulb is the basis for getting to comprehend the coding mechanism of olfactory system. The glomerulus contains many complex microcircuits which perform a variety of different operations on olfactory inputs, playing an important role in the olfactory information processing. Periglomerular cells are important interneurons that forming the glomerulus circuits and their functional role is not well understood yet. Periglomerular cells are heterogeneous. A subpopulation of periglomerular cells fire plateau potential under stimulus. The plateau potential periglomerular cells can convert the high-frequency input of olfactory sensory axons into a low-frequency output; they are likely to participate in the regulation of the timing of glomerulus activities. More and more attention has been paid to these cells. This thesis aims to build a network model of the glomerular incorprating plateau potential cells, mitral cells and the synapses between them.A research platform for olfactory information processing was established and the function of plateau potential periglomerular cells in the glomerulus network was analysised.In this thesis, the anatomical structure and mechanisms of olfactory system were introduced, the characters and research improvement of glomerular were described, and the physiological properties of periglomerular cells and the research improvement of periglomerular cells were described; Secondly, neuron cable model, kinetic model of ion channels and synaptic dynamics model used in the network model were described, and the modeling software were introduced; Thirdly, the topological structure of the network model and the parameter settings of cell models and the synapse models were described; Finally, the function of plateau potential periglomerular cells in olfactory information coding were analyzed based on this model, found that plateau potential periglomerular cells can synchronize the spiking of mitral cells projecting to the same glomerular.. The model constructed here provides a good platform for studying the mechanisms of olfactory system; meanwhile, the research results of this paper lay a good foundation for the further study of olfactory coding.