The Lack Of Sensory Nerve Affect The Regeneration Of Motor Nerve

Objective：In this experiment, we establish a rat modal of selective sensory denervation toresearch that the lack of senAry nerve affect the regeneration of motor nerve.Methods:we select38Wistar rats as experimental animals, selectively cutting off one sideof the dorsal root (L4-L6) is the deal with factors. We make the rat modal about thetibial nerve transection, meanwhile, select the method of epineurial neurorrhaphy andrepair the injured tibial nerve immediately. Groups:(1) control group(A group): it wasexposed the right side of L4,-L6spinal nerve root,then, cut the right tibial nerve andimmediately line the epineurium suture;(2) experimental group(B group): the sameway to design the incision, exposing the right side of L4-6root of spinal nerves，butwhere we will cut off is the ends of Dorsal root of spinal ganglion area. This step needMicrosurgery scisars.Results:(1)12weeks after surgery, we observed that all the injured tibial nerve of thetwo groups rats can be healed;(2) the method, which is used to cut off one side of theL4-L6dorsal root in rats of the experimental group and control group, can be satisfiedwith the simulation of selective senAry nerve damage;(3) the injured nerve functionalrecovery of the experimental group show the difference compared with the controlgroup. Experimental test results: the experimental group of rat gastrocnemius musclewet weight recovery rate was lower than the rats in the control group, but the atrophydegree of the gastrocnemius muscle higher than that in the control group; for NCV(tibial nerve conduction velocity) and CAMP (gastrocnemius muscle evoked actionpotential amplitude) of two indicators, rats in the experimental group weresignificantly lower than the control group of rats. All the three data through independent sample t test analysis, according to a=0.05level, the difference wasstatistically significant (P <0.01).Conclusion:The results of this experiment shows that senAry nerve have an influence on thehealing of the motor nerve; motor function of the injury healing motor nerve will bereduced; Experimental test results: the movements of the ipsilateral limb becomelack of coordination; the nerve conduction velocitiy become slowly; thegastrocnemius muscle atrophy; the volatility of the gastrocnemius EMG had beendecreased and the injury potential had been found.