Panax Notoginseng Saponins Regulate Experimental Study Of The Upper Respiratory Tract Flora And Local Immune Mice

[Objective]This study to select the Yunnan geoherbs notoginseng main functional ingredient ofPanax notoginseng saponins, upper respiratory tract flora and localimmunocompromised mouse model of regulatory intervention by observing thedominant bacteria of the upper respiratory tract in mice, dense flora, bacteria SIgAchanges in the population diversity and local mucosal immune molecules, in order ofPanax notoginseng saponins to play through the blood circulation in the efficacy ofanti-inflammatory and immune regulation, and thus the role of the respiratory tract floraand local immune molecules to regulate for the upper respiratory tract infectionprevention and control of traditional Chinese medicine microbial modulator to providenew ideas.[Method]An intraperitoneal injection of penicillin and cyclophosphamide to establish the upperrespiratory tract flora and local immunocompromised mouse model.2, respectively, before modeling, modeling, and7days after the administration of theend of the mice was detected by oropharyngealflora density, Streptococcus, floradiversity and mucosal immune molecules SIgA content, and then analysis of Panaxnotoginseng saponins on mouth pharynx microecological in mice and local mucosalimmune molecules SIgA regulatory role. [Results]Penicillin, cyclophosphamide and combined use of mouse oropharynx microecology andmucosal immune molecules SIgA compared with the control group (negative controlgroup): the dominant bacteria Streptococcus was not detected (P <0.01. The); floraintensity decreased (P <0.05); diversity was significantly lower (P <0.01). Mouse saliva,mucosal immune molecules SIgA decreased (P <0.05) The results prove the model ofthe upper respiratory tract flora and local immunocompromised mouse model.The two drugs after the intervention of PNS (PNS group) NS (NS group): the mouseoropharynx dominant bacteria in the Streptococcus and flora intensity increased (P<0.05) increase in bacterial diversity (P <0.01), SIgA content of saliva, mucosal immunemolecules in the saliva of mice were increased(P <0.05).