The Study On The Correlations Between VEGF、ES、TSP And Angiogenesis In Diabetic Retinopathy(DR)

Objective: To investigate the levels of VEGF、 ES、TSP in plasma and their relations to the grades of DR patiences, the correlations of stimulators and inhibitors of angiogenesis in diabetic retinopathy.Methods:plasma samples were obtained from51diabetic retinopathy patients (observation group) and10diabetic metabolism patients(control group). The level of VEGF、 ES and TSP weremeasured simultaneously in each specimen by enzyme-linked immunosorbentassay(ELLISA). The indexes were compared, the correlations between VEGF、 ES、 TSP and the grades of DR were discussed. The correlations of stimulators and inhibitors of angiogenesis in diabetic retinopathy were also discussed.Results:The level of VEGF which have been in the status of diabetic retinopathy had statistical significance among five groups(devided by extent of retinopathy)(P<0.05), and the index increased when the stage of retinopathy developed. The level of ES which have been in the status of diabetic retinopathy had statistical significance among five groups(devided by extent of retinopathy) in the status of control group and NPDR patients (P<0.05),, the index increased when the stage of retinopathy developed, but in PDR patients, the index significantly decreased. The level of TSP which have been in the status of diabetic retinopathy had no statistical significance among five groups(devided by extent of retinopathy)(P>0.05). VEGF was significantly correlated with the grades of DR(r=0.84,P<0.05), ES was significantly correlated with the grades of control group and NPDR patiences (r=0.82,P<0.05), TSP was not correlated with the grades of DR patients (r=-0.06p>0.05). VEGF was correlated with ES in control group and NPDR patients(r=0.73,p<0.05),but was not in PDR patients(r=0.01,p>0.05), VEGF and TSP was not correlated with in DR patients (r=-0.13,p>0.05), ES and TSP was not correlated with in DR patients (r=0.01,p>0.05)Conclusion: The plasma level of VEGF and ES were in balance in nonproliferativediabetic retinopathy, the imbalance of VEGF and ES may determine the angiogenesis in proliferative diabetic retinopathy patients, This proved that the imbalance of stimulators and inhibitors may be the causes of angiogenesis in diabetic retinopathy.