Effects Of Rosuvastatin On Lipoprotein, High-sensitivity C-reactive Protein And Atherosclerosis In Patients With Acute Cerebral Infarction

Objective:To observe the effects of Rosuvastatin on lipoprotein, high-sensitivity C-reactive protein, atherosclerosis, cerebral hemodynamics and ischemic stroke recurrence in patients with acute cerebral infarction.Methods:The study was performed in Wuxi people’s hospital from2011～01to2011～10.158cases of patients with acute cerebral infarction were enrolled. All the patients were tested high-sensitivity C-reactive protein (hs-CRP), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and used the internal carotid artery color doppler ultrasound machine to detect the artery intima-media thickness (IMT), the condition of carotid atherosclerosis, carotid artery stenosis and unstable plaque, and complete transcranial doppler (TCD) to detect the mean velocity (Vm) of blood flow, systolic velocity (Vs) of blood flow, pulse index(PI) of bilateral middle cerebral arteries. All patients were treated with rosuvastatin10mg/d,68patients adhered to statin therapy for6months. The change of hs-CRP was analyzed after one week of rosuvastatin therapy. After6months, the levels of TC, TG, LDL-C, HDL-C, all were compared with those of baseline. After6months, the situation of carotid artery ultrasonagraphy and TCD were compared with those of baseline. The stroke recurrence rate was compared between the group keeping treatment of rosuvastatin and the other group discontinuing the treatment.Results:壹、After one week treatment of rosuvastatin, the hs-CRP level of68patients keeping treatment of rosuvastatin with acute cerebral infarction was lower than those of baseline, and P<0.05.贰、After6months treatment of rosuvastatin, the TC,TG, LDL-C levels of68patients keeping treatment of rosuvastatin were lower than those of baseline, the HDL-C level was higher than those of baseline, and the changes all have statistical meaning(P<0.05). The LDL-C level was significantly lower(P<0.01).叁、After6months treatment of rosuvastatin, the carotid artery intima-media thickness (IMT) and the rate of unstable plaques of68patients keeping treatment of rosuvastatin were lower than those of baseline. At the same time, the situation of carotid atherosclerosis and carotid artery stenosis improved. All the changes were significant(P <0.05).肆、After6months treatment of rosuvastatin, the Vm, Vs levels of68patients keeping treatment of rosuvastatin were significantly higher, the PI level was significantly lower(P<0.05).伍、The stroke recurrence rate of the group keeping rosuvastatin was lower than that of the group discontinuing the treatment(P<0.05).陆、After6months treatment of rosuvastatin, the68patients keeping treatment of rosuvastatin showed no marked adverse reaction.Conclusion:Rosuvastatin can significantly reduce the levels of hs-CRP,LDL-C,TC,TG, increase the level of HDL-C, and make the plaque stable and reversal. Rosuvastatin has significant anti-artery atherosclerosis effect.It can improve cerebral hemodynamics in patients with cerebral infarction and reduce the stroke recurrence rate, and have no serious adverse events. So, Rosuvastatin can be used generally in the secondary prevention of cerebral ischemic stroke.