A Comparison Between Alendronate And Calcitonin On The Prevention Of The Secondary Osteolysis Around The Prosthesis And The Prosthetic Loosening After Total Hip Atrhroplasty Of Senior Osteoporosis Patients

Objectives: Compare the prevention effect of alendronate and calcitonin tosecondary osteolysis around the prosthesis and the prosthetic loosening aftertotal hip arthroplasty of senior osteoporosis patients, and observe their painrelief effect shortly after the operation.Methods: From the senior patients with femoral neck fracture and havingreceived total hip arthroplasty, measure the bone mineral density of the femoralneck and femoral shaft around the prosthesis one week after the operation toevaluate whether the patients suffer osteoporosis. Collect and analyze81caseswith osteoporosis and femoral neck fracture, and conduct total hip arthroplasty.Then randomly divide them into combination group, treatment group andcontrol group, with each group having27cases. Treat the combination groupwith both oral alendronate and injected calcitonin, the treatment group with oralalendronate, and the no treatment to the control group. Compare the changes ofbone mineral density around the prosthesis, early analgesic effect and long-termprosthesis loosening rate of the patients after operation.Results: The bone mineral density change of proximal femor and femoralshaft around the prosthesis of the combination group and the treatment group isremarkably higher than that of the control group, and it has statisticallysignificant difference（P<0.05）. However, the average bone mineral densityaround the prosthesis of the combination group is higher than that of thetreatment group, and it has no statistically significant difference（P＞0.05）.The prosthesis loosening rate after two full years of the combination group andtreatment group is remarkably lower than that of the control group, and it hasstatistically significant difference（P<0.05）. By means of VAS appraising fromaround the hip of the patients three weeks after the operation, the early analgesiceffect of the combination group is remarkably higher than that of the treatmentgroup and control group, and it has statistically significant difference（P<0.05）.Conclusion:1. The statistical results of the study show that for the patientswith osteoporosis and femoral neck fracture, treating them with alendronate andcalcitonin after operation can remarkably increase the bone mineral densityaround the prosthesis and decrease the long-term prosthesis loosening rate.2.For the patients with osteoporosis and femoral neck fracture, treating them withoral alendronate and injected calcitonin after operation can remarkably relievepain.3. The study holds that when taking alendronate, the patients must strictlyfollow the requirements.4. This study will give the patients selected as the studycases necessary health education and has fine enhancement for medicinedependency of the patients.At present, the prosthesis loosening after hip arthroplasty is still a difficultissue for orthopedists. The prosthesis loosening rate of the patients withosteoporosis and femoral neck fracture is even higher. To take alendronate solelyor combine alendronate and calcitonin can not only decrease the long-termprosthesis loosening rate and increase the bone mineral density around theprosthesis, but also effectively relieve pain after operation. As a result, they areof wide application prospect.