Analysis Of Drug Resistance And Risk Factors On485Cases Of Multi-drug Resistant Pseudomonas Aeruginosa Hospital Infection

Objective: Analyze the infection status and drug resistance ofPseudomonas aeruginosa infection in hospital and to explore the relatedrisk factors of multi-drug resistant Pseudomonas aeruginosa hospitalinfection, and to provide theoretical basis for clinical prevention andtreatment of multi-drug resistant Pseudomonas aeruginosa infection.Methods:485strains Pseudomonas aeruginosa were collected inChina-Japanese Union Hospital Jilin University from2012January to2012December， to analyze the epidemic and distribution ofPseudomonas aeruginosa infection. Case control method was used tocompare multi-drug resistant Pseudomonas aeruginosa infection caseswith sensitive Pseudomonas aeruginosa detected in the same period forstatistical analysis.The drug sensitivity were analyzed by Kirby-Bauerpaper diffusion method,and the multiple drug resistance of Pseudomonasaeruginosa were screened.The epidemiological information of thesepatients were reviewed retrospectively. Risk factors were analyzed byunivariate and multivariate analysis in unconditional Logistic regressionModel.Results: The main departments of Pseudomonas aeruginosainfectionin were neurosurgery and Respiratory medicine in ourhospital;Drug susceptibility test of13kinds of antibiotics resistance rateof Pseudomonas aeruginosa showed the rate of drug resistance of lower including amikacin (10.8%), levofloxacin (14.9%) and cefepime(16.2%), imipenem, ammonia aztreonam and cefotaxime resistancerate is higher, respectively26.8%,44.9%and94.2%. The multipleresistant strains accounted for113cases, reaching23.3%; Single factoranalysis showed: these factors incluing Hypertension, cerebrovascularaccident combined, hospitalization time, the use of carbapenemantibiotics, quinolones, the use of more than3kinds of antibiotics,antibiotic use number of days, sputum, ventilator, tracheal intubation,deep venous cannula, nasogastric intubation, catheter,mixed infection ofBauman Acinetobacter, fungal infection, mixed infection pathogen≥3were associated with multi-drug resistant Pseudomonas aeruginosainfection (P<0.05); Multivariate Logistic regression analysis showedthat the use of antibiotics, the use of carbapenem antibiotics and trachealintubation were independent risk factors of multi-drug resistantPseudomonas aeruginosa infection.Conclusion:1.Antibiotics which had the higher resistance rate of Pseudomonasaeruginosa in485strains were cefotaxime, aztreonam, imipenem inproper order.2.These factors incluing combined with Hypertension,cerebrovascular accident combined, hospitalization time, the use of carbapenem antibiotics, quinolones, the use of more than3kinds ofantibiotics, antibiotic use number of days, sputum, ventilator, trachealintubation, deep venous cannula, nasogastric intubation, catheter,mixedinfection of Bauman Acinetobacter, fungal infection, mixed infectionpathogen≥3were associated with multi-drug resistant Pseudomonasaeruginosa infection.3.The use of antibiotics, the use of carbapenem antibiotics andtracheal intubation were independent risk factors of multi-drug resistantPseudomonas aeruginosa infection.