The Clinical Study Of Combined Detection Of Serum CEA，CA19-9and AFP In The Diagnosis And Differential Diagnosis Of Patients With Cholangiocarcinoma

Objective:To detect the single or combined level of CEA、CA199、AFPin patients with cholangiocarcinoma,we analysis the clinicalsignificance for early diagnosis of cholangiocarcinoma.Methods:Automatic chemilum inescence immunoassay was used to detectthe serum level of CEA、 CA199and AFP in patients withcholangiocarcinoma15、hepatocellular carcinoma16、liver cirrhosis30and the healthy people22.Compare the differences between thesegroups.Results: In comparion with the HCC、hepatocirrhosis and the controlgroups,the level of CA199and CEA are higher in patients withcholangiocarcinoma (P<0.05). The levels of AFP in patients withhepatocellular carcinoma was higher than that in patients with HCC、hepatocirrhosis and the control groups (P<0.05).The combineddetection of CA199and CEA for the relevance rate of CC is higherthan the single detection（P＜0.05）.Conclusions:The detection of CA19-9is valuable in the earlydiagnosis of CC.The detection of AFP is valuable in the earlydiagnosis of HCC.Combined detection of serum CA19-9and CEA inpatients with CC could improve the sensitivity of diagnosis.