Clinical Analysis Of Neural Invasion In Pancreatic Cancer

Objective:To study the situation of neural invasion in the specimens of pancreatic cancer that underwent operation (include intra-panceatic neural invasion and external-pancreatic neural invasion)and investigate its related clinical factors.Methods:1,Collect the relevant informationxollect73pancreatic cancer cases that underwent radical operation between January2001and December2012in the Panceatic and splenic surgery of Nanjing Drum Tower hospital,get the information of patients’name,sexual distinction,age,illess,with or without diabetes mellitus,have or have not abdominal pain,the site of tumor, the report of pathology,prognosis and survival time;2,Contact the department of pathology,obtain the primary pathological sections and paraffin blocks,review these sections and verify the neural invasion,pathological type,degree of differentiation,tumor size,lyphnode metastasis and the immunohistochemical results.some27cases’sections between January2001and December2004did not make the test of immunohistochemistry,we use the immunohistochemistry technique to analysis the expression of EGFR and VEGF. Then input the above information into database;3.According the presence or absence of neural invasion,73cases were divided into two groups,through the statistical analysis software of SPSS13.0we obtained the correlation between the neural invasion with gender,age,abdominal pain,diabetes mellitus,the site of the tumor,pathological type, degree of differentiation,lyphnode metastasis,vascular invasion,immunohistochemical expression of EGFR and VEGF, and survival rate.Results:In73cases of pancreatic cancer,neural invasion occurred in38(52.1%)patients, among whom intra-pancreatic neural invasion rate was15.8%(n=6); and both intra-pancreatic and external pancreatic plexus invasion rate was84.2%(n=32). Neural invasion was not related with gender,age,and pathological type,degree of differentiation,tumor size and lymph node metastasis(P>0.05). But the presence of abdominal pain, vascular invasion, the expression of EGFR and VEGF in tumor tissue was significantly related with neural invasion(P<0.01). the median survival of patients in neural invasion group was8months, which were significantly shorter than that of in patients without neural invasion(13months, x2=4.69, P=0.030).Colclusion:Neural invasion has a high incidence in pancreatic cancer, and it can cause obvious abdominal pain. And it is related with vascular invasion and the expression of EGFR and VEGF in tumor tissue. Neural invasion is one of the factors affecting the survival rate.