The Research On Curative Effect And Influence Of MMP-9with Lung Qi Deficiency Type Of Chronic Obstructive Pulmonary Disease In Stable Phase By Bufei First Prescription

Objective:Using Bufei first prescription to treat Lung Qi deficiency type of chronic obstructive pulmonary disease patients with stationary phase, Through the observation the change of patients with clinical symptoms, BODE index and peripheral blood MMP-9testing in the treatment of before and after, In system evaluation for Bufei first prescription in the treatment of chronic obstructive pulmonary disease stationary phase of clinical curative effect.Methods:In strict accordance with the subject of the design criteria and exclusion standard selection of patients with chronic obstructive pulmonary disease patients sixty cases of stationary phase, Using randomized controlled clinical trial design method divided into treatment group and control group, According to the1:1design, each group30cases each,Among them, The control group to the Doxofylline Tablets treatment, Treatment group to the traditional Chinese medicine Bufei first prescription combination of doxofylline Tablets treatment,Two groups of treatment time are2months (one period of treatment), After statistics processing. Analysis of the patient’s clinical symptoms, BODE index and peripheral blood MMP-9in the improvement of the situation before and after treatment.Results:1.The treatment group before and after treatment of traditional Chinese medical syndrome of comparison, All have significant difference (P<0.05); Control group in cough, sputum, wheezing, shortness of breath, Compared with before treatment, also improved (P<0.05). The rest did not see symptoms improve, no statistical significance (P>0.05); Treatment group compared with control group after treatment, in addition to coughing, coughing up phlegm, shortness of breath and wheezing, residual index had significant difference (P<0.05). Compared two groups of curative effect of traditional Chinese medicine, treatment group total effective rate was92.86%, control group total effective rate was77.78%, compared two groups of curative effect have significant difference (P<0.05), shows that the curative effect of treatment group is better than the control group.2. Two groups of BODE index comparison:Treatment group after treatment difficulty breathing,6minutes walking distance and the BODE index was have the significant difference (P<0.05), More than no improvement; Control group in addition to difficulty breathing outside, the rest each index and the total score than before treatment did not see significant difference (P>0.05); Compared the two groups after treatment, the treatment group only in6minutes walking distance from the control group had significant difference (P <0.05), the rest of the indicators are no significant difference (P>0.05). Results showed that the treatment group can improve the patients’ degree of difficulty in breathing and body movement endurance.3. The influence of MMP-9:Treatment group in peripheral blood MMP-9a significant decrease in before treatment, there is significant difference (P<0.05); Control group peripheral MMP-9is not seen before treatment significantly decreased (P>0.05). The treatment group in improving MMP-9and compared to control group with significant difference (P<0.05).Conclusions:Control group and treatment group according to the project design scheme is given after processing. Results show that Bufei first prescription combined with Doxofylline Tablets treatment of Lung Qi deficiency type stabilization period of COPD patients, compared with pure western medicine treatment, can better improve the patient’s clinical symptoms, increase exercise endurance and reduce the expression of MMP-9levels, so as to more effectively improve the patient’s quality of life, can be popularized in clinical application.