Research On Material Basis And Related Pharmacodynamics Of Coked Chinese Hawthorn Based On Traditional Efficacy

This topic takes the clinical commonly used Chinese medicine hawthorn as the model medicine, by means of modern technology, systemly research main chemical composition and efficacy function change pre and post the drug frying coke. It is for the purpose of exploring the material basis and mechanism the burnt Chinese hawthorn determination of Hesperidin, in order to provide the scientific basis to clarify the burnt Hawthorn processing principle.In order to investigate Chinese hawthorn frying coke influence to the digestion functions, this research has carried out the preliminary pharmacodynamics research. Through the normal mouse’s stomach evacuation and the small intestine propulsion experiment, small intestine the atropine shoulders advance the experiment and the gastric juice secretion experiment, investigated burnt hawthorn impact on digestive system The experimental result indicated that the net Chinese hawthorn and the burnt Chinese hawthorn have the obvious promoter action to the stomach and intestines movement and the stomach evacuation, and the burnt Chinese hawthorn’s function is better than the net Chinese hawthorn. The research also carried on the net Chinese hawthorn, the burnt Chinese hawthorn to stop the senna leaf result diarrhea mouse flows swiftly and the intestinal tract bacteria colony influence experiment, the results indicated that the burnt Chinese hawthorn could reduce the mouse bowel movement number of times, the thin then degree and quantity effectively. The burnt Chinese hawthorn has certainly enhances the mouse intestinal tract bacteria colony, improve environment function of mouse intestinal tract bacteria colony,In the chemical composition analysis, this research examines the Chinese hawthorn main chemical composition pre and post the drug frying coke, to reveal the variation of the chemical composition of the hawthorn pre and post frying coke. Through analysis of for samples pre and post frying coke, discovered that after the Chinese hawthorn frying coke, ultraviolet spectrum has great differences. But after frying coke, there are characteristic peaks increased in the ultraviolet spectrum, indicates that possibly has the new composition that Chinese hawthorn itself does not exist or the content is very low which cannot pick out. GC-MS analysis of the net hawthorn and burnt hawthorn focus study found that burnt hawthorn citric acid, palmitic acid, oleic acid, malic acid and other contents were decreased, but there was a substantial rise of the compounds at4.12min, at the6.76min a new compound or a new class of compounds are found, the compounds of the12.39min and14.64min the contents were increased, and a lot of the compounds has not been found in the NISTFF MSL database, so suggesting that the change of these compounds changes is related to pharmacodynamics change of hawthorn frying coke. The antidiarrheal material basis of burnt hawthorn digestion requires further research, this study finds a starting point for in-depth study of Hawthorn frying coke processing principle.In order to explore the material basis of pharmacological effects of changes for the burnt hawthorn, this study uses rice as a control, the experiment of uncooked rice water, coked rice water on diarrhea in mice caused by senna to stop diarrhea and intestinal flora has been done, the experimental results show that the coked rice water can effectively reduce the frequency of defecation, loose stools and volume of mice, has a certain extent to improve the environment of the intestinal flora of mice. Coked rice water digestion antidiarrheal effect of this experimental study is proposed for control of the study of the burnt hawthorn, provide a reference to explore frying coke common problems. Infer material basis of burnt hawthorn, coked rice diarrhea in mice may relate to frying coke process of caramelization and Maillard reaction to produce new substances, the material foundation needs further study.In summary, this study use the application of biotechnology, chemical analysis technology of modern science and research chemical composition changes the hawthorn frying coke, revealing the variation of the ultraviolet spectrum pre and post hawthorn frying coke; on the basis of the chemical composition change pre and post hawthorn frying coke research, study the pharmacological digestion effect on the net hawthorn and burnt hawthorn, confirmed the burnt hawthorn "be good at digestion antidiarrheal" medication theory. Of this research project ideas and techniques, for the aim to provide a reference for other drugs frying coke research.