The Study On Correlative Factors As Syndrome Of Spleen Deficiency And Translocase Of Outer Mitochondrial Membrane40Homolog In Type2Diabetic Patients With Mild Cognitive Impairment

Objective: To further clarify the risk factors and pathogenesis of type2diabetic patients with mild cognitive impairment, and support the combination of traditional Chinese and Western medicine in treatment of T2DM with MCI from the perspective of Evidence-Based Medicine. This study was carried out to detect the associations of the syndrome of spleen deficiency and the polymorphism of translocase of outer mitochondrial membrane40homolog’s locus rs10524523with T2DM with MCI.Methods:176cases of patients with type2diabetes were analyzed by rating scales of MoCA, IADL,MMSE,and so on. The polymorphism of translocase of outer mitochondrial membrane40homolog’s locus rs10524523,together with serum biochemical indicators including red blood cell, hemoglobin, albumin,and so on were measured at the same time.All patients were divided into two groups: type2diabetes mellitus with mild cognitive impairment group(104cases)and type2diabetes mellitus with normal cognitive function group(72cases).In addition,the type2diabetes mellitus with mild cognitive impairment group was divided into syndrome of spleen deficiency group(56cases) and non-syndrome of spleen deficiency group(48cases) according to the standard of the syndrome differentiation of traditional Chinese medicine.The gene frequencies and the clinical data were compared among the groups.Results:(1) The duration of diabetes,the levels of HbAlC,CRP,TG and LDL and the MoCA score of type2diabetes mellitus with MCI group were significant higher than the control group. Besides, the levels of CHOL and the distribution of the deleted gene between them was significant different.Futhermore, all the differences have statistical significance.But there were no significant differences among gender, age, body mass index, waist circumference, the level of HDL, with or without a history of hypertension, smoking, and family history of diabetes between the two groups.(2) The levels of red blood cell,hemoglobin,albumin and the distribution of thedeleted gene between the syndrome of spleen deficiency group and the non-syndrome of spleen deficiency group were different with statistical signigecance. Equally, all the differences have statistical significance. But there were no significant differences among the leves of HbAlC, blood lipid and CRP, gender, age and other clinical features between the two groups. Conclusionsr(1) MCI had relations with the duration and the control status of blood glucose of type2diabetes mellitus.(2) Syndrome of spleen deficiency can affect the initiation and development of mild cognitive impairment in type2diabetic mellitus. The method of invigorate the spleen plays an important role in treating this category of diseases by traditional Chinese medicine.(3) Detection of the polymorphism of TOMM40gene rs10524523could predict risk for cognitive impairment in type2diabetic mellitus to some extent.(4) Complementation of invigorating the spleen and genetic testing may exert a more immense effect on the diagnosis and treatment of type2diabetic patients with mild cognitive impairment.