Yi Qi Gu Biao Tang Of Mouse Serum In Asthma And IL-4, IL-13Levels Affect Experimental Study

Objective: This study was designed by feeding the mice given gavage lungssolid table, Qi righting “Yi qi gu biao tang”to improve immune functionin mice, the mice20days after doing provocation experiment, and observationof Qi solid form soup can delay an asthma attack, and assessed by serum IL-4,IL-13content of the role of “Yi qi gu biao tang” whether there is controlthe airway inflammation and thus to prevent asthma attacks. Provide atheoretical basis for the clinical application of Yi qi gu biao tang.Method: Under the same conditions, fed with normal diet mice, theadaptability of the40mice fed for three days, and then divided into blankcontrol group, saline gavage control group, Qi solid form Tang high-dosegroup, Qi solid form of soup, small dose group n=10, control group withnormal diet feeding, the remaining three groups in addition to normalordinary feeding, saline group fed with0.3ml of saline each time, once aday; Qi solid form soup irrigation of large-dose group feed concentrationof1.112g/ml Qi solid form soup, each0.3ml daily; Qi solid form soup,small-dose group were fed concentrations of0.556g/ml Qi solid form soupeach0.3ml, day1; were fed for30days. The20days to do provocation, eachgroup of mice by intraperitoneal injection of4%egg protein1ml sensitized7days sensitized mice were individually placed in transparent, sealedorganic glass, give isotonic containing1%ovalbumin atomization inhalationof saline, once daily, each for10min, a total of three days to observe themice in each group of asthma symptoms in time and serum IL-4, IL-13contentchanges.Results: Yi qi gu biao tang can delay the time of an asthma attack, and serum IL-4, IL-13detection Yi qi gu biao tang to control inflammation in mouseasthma attack, the most obvious effect of high-dose group.(Statisticalsignificance P <0.01or P <0.05)Conclusion: Yi qi gu biao tang can delay an asthma attack to control theinflammatory response.