The Protective Effect And Mechanism Of Liuwei Dihuang Pill In Bone Metastases Patients With Non-Small Cell Lung Cancer

Objective:1. To observe the clinical efficacy on Liuwei Dihuang Pill combined with bisphosphonate in bone metastases patients with NSCLC;2. To observe the influence of serum NTx and serum RANKL on Liuwei Dihuang Pill combined with bisphosphonate in bone metastases patients with NSCLC, and preliminary explore the mechanisms of protective effect.Methods:Select60patients who were diagnosed as bone metastases with NSCLC by pathology department and imageology department of Fuzhou General Hospital of Nanjing Military Area from February2011to December2011. Divide randomly into experimental group and control group, with each group30cases. The experimental group used both Liuwei Dihuang Pill and bisphosphonate, and the control group use bisphosphonate only. Observe KPS, bone metastases focus and detect the values of NTx, OPG and RANKL of peripheral blood with ELISA in the2groups before and after3months treatment. Analyze by SPSS16.0statistical software.Results:Before treatment, there were no significance statistically between2group in age, gender, pathological type, part of bone metastases, amount of bone metastases, KPS, sNTx, sOPG and sRANKL. After3months treatment, KPS significantly elevated in experimental group (P<0.01) while there was significant difference between2group (P<0.05). sNTx significantly declined in experimental group (P<0.01), while there was significant difference between2group (P<0.01). sOPG significantly elevated in experimental group (P<0.01), while there was significant difference between2group (P<0.01). sRANKL significantly declined in experimental group (P <0.01), while there was difference between2group (P<0.05). Experimental group had higher efficiency than control group in bone metastases focus, but there was no significant difference (P>0.05)Conclusion:1. Liuwei Dihuang Pill combined with bisphosphonate contribute to raise KPS and had a trend to raise efficiency in bone metastases focus, could morely significantly decline sNTx.2. Liuwei Dihuang Pill combined with bisphosphonate could elevate sOPG and decline sRANKL, and then restrained osteoclast mature, which was the way to make a protective effect.