The Relationship Between Hyperuricemia With Metabolic Syndrome And IMT In Male

Objective: To analyzes the relationship between serum uric acid levels withmetabolic syndrome components, insulin resistance and intima-media thicknessin male.Methods: Select217cases of the male patients with HUA who diagnosis andtreatment in Guangxi Medical University first affiliated hospital during January2007and January2012. Collection includes serum uric acid, body mass Index(BMI), blood pressure (BP), Fasting blood glucose (FBG/PBG2h), Totalcholesterol (T-Cho), Triglycerides (TG), High-density lipoprotein-cholesterol(HDL-C), Low-density lipoprotein-cholesterol (LDL-C), intima-Mediathickness(IMT), calculate the nonHigh-density lipoprotein(nonHDL-C), Fastinginsulin resistance index (FInRI) and insulin sensitivity index (IAI) values, usingthe SPSS16.0software to analyze the relationship between SUA and otherfactors.Results:1. The male patients with HUA, age from25to88s, SUA in the age layeredhave no obvious difference (rs=1.000，P=0.102).2. With SUA concentration increases, T-Cho, nonHDL-C, BMI increased (p <0.05), which the BMI is higher (p <0.01). And SBP, DBP, FBG, PBG2h, TG,HDL-c, LDL-C all have no obvious correlation (p>0.05). 3. As UA concentration increases, the prevalence of high blood pressure haverisen (P <0.05), and dyslipidemia and blood glucose abnormalities indifferent rates in the layer UA have no obvious difference (P>0.05), angMS related components have clustered the better (χ2=14.457, P=0.036)4. When SUA concentration or BMI have increased, the FINS and FInRI willincrease, IAI down (P <0.05).5. IR and UA (P=0.039, OR=1.007), BMI (P=0.030, OR=1.195), MS (P=0.004, OR=7.480) were independent related. For UA and MS interactionanalysis, HUA with MS has the significant effect for IR (P=0.042, OR=1.004).6. Only137samples have IMT, the minimum value is0.50mm, a maximum of2.50mm, an average of1.140±0.034mm mm, among them,36.50%werenormal,40.14%were thickening and23.36%have the plaques.7. IMT and UA were positively related (P <0.05).8. IMT and UA (P=0.045, OR=1.004), MS (P=0.003, OR=3.958) wereindependent related. For UA and MS interaction analysis, HUA with MS hassignificant influence for thickening of IMT (P=0.047, OR=1.003).Conclusion:1. The male patients with HUA, T-Cho, T-nonHDL-C, BMI were positivelyrelated with UA concentration, wathever, the association of BP, bloodglucose, TG, HDL-C and LDL-C was not significant. 2. As UA concentration increased, MS related components have clustered thebetter.3. When SUA concentration or BMI have increased, the FINS and FInRI willincrease, IAI down. UA, BMI, MS were independent influence factors of theIR, HUA with MS has the significant effect for IR.4. IMT was positively related with UA concentration. UA, MS wereindependent factors of IMT, HUA with MS has significant influence forthickening of IMT.