Acupuncture And Cupping Combined With Leflunomide In The Treatment Of Anti-CCP Antibody-positive Clinical Observation Of Early Rheumatoid Arthritis

Objectives:Through clinical trials research, observation the effectiveness of the needle cans the Joint leflunomide in the treatment of anti-cyclic citrulline peptide (CCP) antibodypos-itive the early rheumatoid arthritis (ERA), for the needle cupping therapy on with early rheumatoidarthritis provide a reliable basis, and to explore the role of leflunomide in Reducing Toxicity and CCP concentration, providing a safe and effective solution for Integrative treatment of anti-CCP antibody positive early rheumatoid arthritis.Methods:Use of random parallel control method,66cases of early RA patients with anti-CCP antibody-positive random number table is divided into33cases of the treatment group and the control group of33cases, all cases are for the2010to2011in Wuhan Hospital of traditional Chinese medicine and acupuncture clinic of Rheumatology clinic and hospital patients. Treatment with acupuncture and cupping therapy (filiform needle acupuncture, electro-acupuncture, back-Shu points and cupping) combined with oral administration of Leflunomide in the treatment, control group oral Leflunomide treatment. Statistics and analysis of therapeutic effect after3months. Observe the two sets of2cases fall off at the end, finally included in the statistical analysis of a total of62cases. Select rest joint pain, joint pain, joint swelling, involvement of number, duration of morning stiffness, the average hand grip with both hands, and acute phase reactants of erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP) and serum markers of rheumatoid factor (RF) and Anti-Cyclic Citrullinated Peptide (CCP) antibodies for clinical outcome measures, and analysis of the clinical effect of total. Use CCP, ESR, CRP early RA disease before and after treatment of numerical information on mitigation effects of statistical analysis and effect of Leflunomide and statistical analysis of the relationship between concentration of anti-CCP antibody. Observation of adverse reaction of indicators as elevated liver enzymes, leukopenia, diarrhoea, anorexia, etc.Laboratory indicators of blood analysis, stool and occult blood analysis, urine analysis, liver and kidney function, rheumatoid full set of anti-"0" full, CRP and CCP, electrolytes, electrocardiogram, chest radiograph, hands ray films, etc, all of the above pre-treatmentindicators must be monitored. After treatment in which blood analysis, liver and kidney function an average monitoring time, while the anti-"0" full of CRP, the CCP indicators treatment three months after the monitoring time. Should record the time of the above indicators before and after treatment, the frequency, duration, severity, measures taken and the outcome of the situation, the ratio of the number, the last comparison before and after treatment SPSS15.0software for statistical analysis of data, numerical The data mean±standard deviation two sets of samples were compared using t-test, the same group before and after treatment were compared using paired t-test,the classification data were analyzed by the X2test, the overall composition than using the X2test. P<0.05or P<0.01, data analysis to test statistically the difference was statistically signif-icant.Results:Total effective treatment is87.1%better than the control group is the Group64.5%, group X2=4.309, P=0.038<0.05, two groups of total effective statistical differences. Description in the treatment group using acupuncture and cupping combined with Leflunomide in the treatment of early RA oral Leflunomide group in overall effect is better than the control group.Two groups of treatment of numerical information for farmer CCP, ESR, CRP, corresponding with the t test p-value is greater than0.05, the three indicators of no difference in the statistics before the treatment, with comparable. After treatment of the two groups of CCP, ESR, CRP numerical data comparison, corresponding with the t test p-value less than0.05, the three indicators statistically difference after the treatment. Instructions using acupuncture and cupping combined with Leflunomide treatment group in palliative treatment of early RA, as well as reduce the CCP, ESR, CRP concentrations than the control group oral Leflunomide. Clinical symptoms of early RA patients reduce the time that corresponds to the CCP, ESR, CRP values are also down.Comparison of numerical information control group before and after treatment of CCP, t=2.581, P=0.012<0.05, statistical differ-rence exists. Description of Leflunomide in RA disease in control at the same time and reduce the concentration of CCP, CCP concentration and extent of early RA is proportional relationship. Treatment and control groups comparing the number of cases of adverse reactions after treatment, inspection concluded that in the X2that corresponds to the p-value is less than0.05, after two groups of treatment of cases of adverse reactions occurring in statistical difference exists. Description of acupuncture-cupping therapy reduces the adverse effects of Leflunomide.Conclusions:Acupuncture and cupping combined with Leflunomide in the treatment of anti-CCP antibody-positive overall effect is better than a control group of patients with early rheumatoid arthritis oral Leflunomide group, in early RA disease mitigation and reduction of CCP, ESR, CRP concentrations than the control group oral Leflunomide, can also reduce the side effects of Leflunomide, is relatively safe, effective, and simple treatment method.